Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, August 20, 2009       Volume 23   Number 8

 

Spotlight

Recommendations Released for Strengthening the Science Base of Personal Genomics
Professionals from government agencies, academic and research institutions, industry, and consumer groups make recommendations for strengthening the science base for using personal genomics to assess risk and prevent disease. A new paper published this month in Genetics in Medicine outlines these recommendations, which are based on a personal genomics workshop hosted by CDC and NIH in December 2008. Access the article  (PDF 416.96 KB).

 

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Announcements

• The National Institutes of Health hosts the State-of-the-Science Conference: Family History and Improving Health on August 24-26, 2009, in Bethesda, Maryland. Deadline for online registration: August 21, 2009.  Click here to register.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Novel microRNA plays a major role in invasive breast cancer development, News-Medical.Net, August 20

USC researchers identify 'regulatory' genetic sequences that may predict risk for prostate cancer, Medical News Today, August 17

Three genetic variants linked to common childhood leukemia found, Medical News Today, August 17

Cardiovascular Disease

Anti-aging gene linked to high blood pressure, Medical News Today, August 20

Epigenetics

Scientists take early steps toward mapping epigenetic variability, Science Daily, August 17

Family History

New online tool helps evaluate family health history, San Marcos Daily Record, August 18

NIH to hold press telebriefing on August 26 following State-of-the-Science Conference on Family History and Improving Health, NIH News, August 18

Know more than the family tree; know the health history, High Plains Journal, August 15

Genetic Testing

Evaluating and regulating personalised genomics, PHG Foundation, August 19

NIH/CDC group publish recommendations for advancing personal genomics, Genome Web, August 19 [by free subscription only]

Testing for genetic mutations within ethnic groups, Los Angeles Times, August 17

Understanding DTC genetic risk prediction services, PHG Foundation, August 14

State laws could cover DTC gene testing, Genome Web, August 13 [by free subscription only]

Infectious Disease

Genes tied to gap in treatment of Hepatitis C, The News York Times, August 16

Mental Health

Common variation in gene linked to structural changes in the brain, Science Daily, August 18

Genetic link between physical pain and social rejection discovered by researchers, Medical News Today, August 18

Mutation tied to need for less sleep is discovered, The New York Times, August 14

Other News

New method for gene expression experiments akin to watercolor painting in water, Medical News Today, August 20

Mutation in Renin gene linked to inherited kidney disease, Medical News Today, August 19

NIH to fund studies on role of genes, social environment in aging, Genome Web, August 19 [by free subscription only]

Faster, cheaper way to find disease genes in human genome passes initial test, Medical News Today, August 18

Francis S. Collins, M.D., Ph.D., sworn in as NIH director, NIH News, August 17

NIH-funded researchers sequence exomes of 12 people, NIH News, August 17

Raising the alarm when DNA goes bad, Nano Werk, August 14

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Genomics in Scientific Literature

 

Family History

Fasting hyperinsulinemia associates with increased sub-clinical inflammation in first-degree relatives normal glucose tolerant women independently of the metabolic syndrome
Setola E, et al.
Diabetes Metab Res Rev 2009 Aug

Reliability of family history of lifestyle-related diseases on questionnaire
Saito T, et al.
Pediatr Int 2009 Aug;51(4):514-9

The impact of family history of type 2 diabetes on pancreatic beta-cell function
Wang ZH, et al.
Diabetes Res Clin Pract 2009 Aug

Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
Ashton-Prolla P, et al.
BMC Cancer 2009 Aug;9(1):283

Genetic Testing

The role of genetic testing in the prediction of response to EGFR inhibitors in NSCLC
Hirsch FR
Oncogene 2009 Aug;28(S1):S1-S3

Genome Wide

Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients
Alkelai A, et al.
Psychopharmacology (Berl) 2009 Aug

Pharmacogenomics

Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors
John T, et al.
Oncogene 2009 Aug;28(S1):S14-S23

General Articles

Functional enhancers at the gene-poor 8q24 cancer-linked locus
Jia L, et al.
PLoS Genet 2009 Aug;5(8):e1000597

Genetic testing for disease susceptibility: a risky business
The Lancet Neurology
Lancet Neurol 2009 Sep;8(9):775

Novel generating protective single nucleotide polymorphism barcode for breast cancer using particle swarm optimization
Yang CH, et al.
Cancer Epidemiol 2009 Aug;33(2):147-54

Severe epilepsy syndromes of early childhood: the link between genetics and pathophysiology with a focus on SCN1A mutations
Stafstrom CE
J Child Neurol 2009 Aug;24(8 Suppl):15S-23S

Estrogen Receptor Polymorphisms: Significance to Human Physiology, Disease and Therapy
Figtree GA, et al.
Recent Pat DNA Gene Seq 2009 Nov

The genetics of human autoimmune disease
Invernizzi P & Gershwin ME
J Autoimmun 2009 Aug

Linking genes to diseases: it's all in the data
Tiffin N, et al.
Genome Med 2009 Aug;1(8):77

Personalized medicine and complementary and alternative medicine: in search of common grounds
Oguamanam C
J Altern Complement Med 2009 Aug;15(8):943-9

Obtaining insurance after DNA diagnostics: a survey among hypertrophic cardiomyopathy mutation carriers
Christiaans I, et al.
Eur J Hum Genet 2009 Aug

Update on genetic predisposition to breast cancer
Ahmed M, et al.
Expert Rev Anticancer Ther 2009 Aug;9(8):1103-13

Pharmacogenetics of Warfarin
Kamali F & Wynne H
Annu Rev Med 2009 Aug

Genetics of Dystonia
Kamm C
Fortschr Neurol Psychiatr 2009 Aug;77(S 01):S32-S36

Epigenomics in Psychiatry
Kato T
Neuropsychobiology 2009 Aug;60(1):2-4

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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