Disclaimer: The information contained in these guidelines is intended for reference purposes only. It provides a summary of information about chemicals that workers may be exposed to in their workplaces. The information may be superseded by new developments in the field of industrial hygiene. Readers are therefore advised to regard these recomendations as general guidelines and to determine whether new information is available.

OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR TRIPHENYL AMINE

INTRODUCTION

This guideline summarizes pertinent information about triphenyl amine for workers and employers as well as for physicians, industrial hygienists, and other occupational safety and health professionals who may need such information to conduct effective occupational safety and health programs. Recommendations may be superseded by new developments in these fields; readers are therefore advised to regard these recommendations as general guidelines and to determine whether new information is available.

SUBSTANCE IDENTIFICATION

* Formula

C(18)H(15)N

* Structure

(For Structure, see paper copy)

* Synonyms

N,N-Diphenylaniline; N,N-diphenylbenzenamine; triphenylamine

* Identifiers

1. CAS No.: 603-34-9

2. RTECS No.: YK2680000

3. Specific DOT number: None

4. Specific DOT label: None

* Appearance and odor

Triphenyl amine is a colorless crystalline solid in the form of monoclinic prisms.

CHEMICAL AND PHYSICAL PROPERTIES

* Physical data

1. Molecular weight: 245.34

2. Boiling point (at 760 mm Hg): 365 degrees C (689 degrees F)

3. Specific gravity: 0.774 at 0 degrees C (32 degrees F)

4. Vapor density: Data not available.

5. Melting point: 127 degrees C (260.6 degrees F)

6. Vapor pressure: Data not available.

7. Solubility: Soluble in benzene and ethyl ether; slightly soluble in ethyl alcohol; insoluble in water.

8. Evaporation rate: Data not available.

* Reactivity

1. Conditions contributing to instability: Exposure to heat, flame and oxygen.

2. Incompatibilities: Contact between triphenyl amine and oxidizing materials, aldehydes, ketones, nitrates, and peroxides should be avoided.

3. Hazardous decomposition products: None reported.

4. Special precautions: None reported.

* Flammability

The National Fire Protection Association has not assigned a flammability rating to triphenyl amine. Other sources rate triphenyl amine as combustible when this substance is exposed to heat or open flame.

1. Flash point: Data not available.

2. Autoignition temperature: Data not available.

3. Flammable limits in air: Data not available.

4. Extinguishant: Use dry chemical or carbon dioxide to fight fires involving triphenyl amine.

Fires involving triphenyl amine should be fought upwind from the maximum distance possible. Isolate the hazard area and deny access to unnecessary personnel. Firefighters should wear a full set of protective clothing and self-contained breathing apparatus when fighting fires involving triphenyl amine.

EXPOSURE LIMITS

* OSHA PEL

The Occupational Safety and Health Administration (OSHA) does not currently regulate triphenyl amine.

* NIOSH REL

The National Institute for Occupational Safety and Health (NIOSH) has established a recommended exposure limit (REL) for triphenyl amine of 5 milligrams per cubic meter (mg/m(3)) of air as a TWA for up to a 10-hour workday and a 40-hour workweek [NIOSH 1992].

* ACGIH TLV

The American Conference of Governmental Industrial Hygienists (ACGIH) has assigned triphenyl amine a threshold limit value (TLV) of 5 mg/m(3) as a TWA for a normal 8-hour workday and a 40-hour workweek [ACGIH 1994, p. 35].

* Rationale for Limits

The NIOSH limit is based on the risk of skin irritation [NIOSH 1992].

The ACGIH limit is based on the risk of adverse health effects [ACGIH 1991, p. 1658].

HEALTH HAZARD INFORMATION

* Routes of Exposure

Exposure to triphenyl amine can occur through inhalation, ingestion, and eye or skin contact.

* Summary of toxicology

1. Effects on Animals: Triphenyl amine has a low toxicity to experimental animals. Crystals of triphenyl amine caused no damage when placed in the eyes of rabbits [ACGIH 1991]. Application of 8 to 16 mg/kg triphenyl amine to guinea pig skin cause only slight erythema with no edema, and no effect was observed following the application of 4 mg/kg to the skin [ACGIH 1991]. Triphenyl amine was not a skin sensitizer in guinea pigs [ACGIH 1991]. The oral LD(50) for rats is between 3,200 and 6,400 mg/kg [ACGIH 1991]. Death was delayed up to 11 days, and ataxia was the only clinical signs of intoxication [ACGIH 1991]. Triphenyl amine was not mutagenic in the Ames assay [ACGIH 1991].

2. Effects on Humans: No adverse effects of exposure to triphenyl amine in humans were identified.

* Signs and symptoms of exposure

1. Acute exposure: No signs or symptoms of acute exposure to triphenyl amine have been reported in humans.

2. Chronic exposure: No signs or symptoms of chronic exposure to triphenyl amine have been reported in humans.

EMERGENCY MEDICAL PROCEDURES

* Emergency medical procedures: [NIOSH to supply]

5. Rescue: Remove an incapacitated worker from further exposure and implement appropriate emergency procedures (e.g., those listed on the Material Safety Data Sheet required by OSHA's Hazard Communication Standard [29 CFR 1910.1200]). All workers should be familiar with emergency procedures, the location and proper use of emergency equipment, and methods of protecting themselves during rescue operations.

EXPOSURE SOURCES AND CONTROL METHODS

The following operations may involve triphenyl amine and lead to worker exposures to this substance:

• The manufacture and transportation of triphenyl amine
• Use as a photoconductor on film bases

Methods that are effective in controlling worker exposures to triphenyl amine, depending on the feasibility of implementation, are as follows:

• Process enclosure
• Local exhaust ventilation
• General dilution ventilation
• Personal protective equipment

Workers responding to a release or potential release of a hazardous substance must be protected as required by paragraph (q) of OSHA's Hazardous Waste Operations and Emergency Response Standard [29 CFR 1910.120].

Good sources of information about control methods are as follows:

1. ACGIH [1992]. Industrial ventilation--a manual of recommended practice. 21st ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

2. Burton DJ [1986]. Industrial ventilation--a self study companion. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

3. Alden JL, Kane JM [1982]. Design of industrial ventilation systems. New York, NY: Industrial Press, Inc.

4. Wadden RA, Scheff PA [1987]. Engineering design for control of workplace hazards. New York, NY: McGraw-Hill.

5. Plog BA [1988]. Fundamentals of industrial hygiene. Chicago, IL: National Safety Council.

WORKPLACE MONITORING AND MEASUREMENT

Determination of a worker's exposure to airborne triphenyl amine is made using a midget fritted glass bubbler (MFGB) containing 15 milliliters of HPLC grade isopropanol. Samples are collected at a recommended flow rate of 1 liter/minute until a recommended collection volume of 250 liters is reached. Analysis is conducted by high performance liquid chromatography using an ultraviolet detector (HPLC/UV). This method is described in the OSHA Computerized Information System [OSHA 1994] and is not yet validated.

PERSONAL HYGIENE PROCEDURES

If triphenyl amine contacts the skin, workers should flush the affected areas immediately with plenty of water, followed by washing with soap and water.

Clothing contaminated with triphenyl amine should be removed immediately, and provisions should be made for the safe removal of the chemical from the clothing. Persons laundering the clothes should be informed of the hazardous properties of triphenyl amine.

A worker who handles triphenyl amine should thoroughly wash hands, forearms, and face with soap and water before eating, using tobacco products, using toilet facilities, applying cosmetics, or taking medication.

Workers should not eat, drink, use tobacco products, apply cosmetics, or take medication in areas where triphenyl amine or a solution containing triphenyl amine is handled, processed, or stored.

STORAGE

Triphenyl amine should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard [29 CFR 1910.1200]. Containers of triphenyl amine should be protected from physical damage and should be stored separately from oxidizing materials, aldehydes, ketones, nitrates, and peroxides should be avoided.

SPILLS AND LEAKS

In the event of a spill or leak involving triphenyl amine, persons not wearing protective equipment and clothing should be restricted from contaminated areas until cleanup has been completed. The following steps should be undertaken following a spill or leak:

1. Collect powdered material in the most convenient and safe manner possible and deposit it into sealed containers.

2. Spilled material may be dampened with a 60 to 70 percent solution of acetone to avoid airborne dust.

SPECIAL REQUIREMENTS

U.S. Environmental Protection Agency (EPA) requirements for emergency planning, reportable quantities of hazardous releases, community right-to-know, and hazardous waste management may change over time. Users are therefore advised to determine periodically whether new information is available.

* Emergency planning requirements

Triphenyl amine is not subject to EPA emergency planning requirements under the Superfund Amendments and Reauthorization Act (SARA) (Title III) in 42 USC 11022.

* Reportable quantity requirements for hazardous releases

A hazardous substance release is defined by EPA as any spilling, leaking, pumping, pouring, emitting, emptying, discharging, injecting, escaping, leaching, dumping, or disposing into the environment (including the abandonment or discarding of contaminated containers) of hazardous substances. In the event of a release that is above the reportable quantity for that chemical, employers are required to notify the proper Federal, State, and local authorities [40 CFR 355.40].

Employers are not required by the emergency release notification provisions in 40 CFR Part 355.40 to notify the National Response Center of an accidental release of triphenyl amine; there is no reportable quantity for this substance.

* Community right-to-know requirements

Employers are not required by EPA in 40 CFR Part 372.30 to submit a Toxic Chemical Release Inventory form (Form R) to EPA reporting the amount of triphenyl amine emitted or released from their facility annually.

* Hazardous waste management requirements

EPA considers a waste to be hazardous if it exhibits any of the following characteristics: ignitability, corrosivity, reactivity, or toxicity as defined in 40 CFR 261.21-261.24. Under the Resource Conservation and Recovery Act (RCRA) [40 USC 6901 et seq.], EPA has specifically listed many chemical wastes as hazardous. Although triphenyl amine is not specifically listed as a hazardous waste under RCRA, EPA requires employers to treat waste as hazardous if it exhibits any of the characteristics discussed above.

Providing detailed information about the removal and disposal of specific chemicals is beyond the scope of this guideline. The U.S. Department of Transportation, EPA, and State and local regulations should be followed to ensure that removal, transport, and disposal of this substance are conducted in accordance with existing regulations. To be certain that chemical waste disposal meets EPA regulatory requirements, employers should address any questions to the RCRA hotline at (703) 412-9810 (in the Washington, D.C. area) or toll-free at (800) 424-9346 (outside Washington, D.C.). In addition, relevant State and local authorities should be contacted for information on any requirements they may have for the waste removal and disposal of this substance.

RESPIRATORY PROTECTION

* Conditions for respirator use

Good industrial hygiene practice requires that engineering controls be used where feasible to reduce workplace concentrations of hazardous materials to the prescribed exposure limit. However, some situations may require the use of respirators to control exposure. Respirators must be worn if the ambient concentration of triphenyl amine exceeds prescribed exposure limits. Respirators may be used (1) before engineering controls have been installed, (2) during work operations such as maintenance or repair activities that involve unknown exposures, (3) during operations that require entry into tanks or closed vessels, and (4) during emergencies. Workers should only use respirators that have been approved by NIOSH and the Mine Safety and Health Administration (MSHA).

* Respiratory protection program

Employers should institute a complete respiratory protection program that, at a minimum, complies with the requirements of OSHA's Respiratory Protection Standard [29 CFR 1910.134]. Such a program must include respirator selection, an evaluation of the worker's ability to perform the work while wearing a respirator, the regular training of personnel, respirator fit testing, periodic workplace monitoring, and regular respirator maintenance, inspection, and cleaning. The implementation of an adequate respiratory protection program (including selection of the correct respirator) requires that a knowledgeable person be in charge of the program and that the program be evaluated regularly. For additional information on the selection and use of respirators and on the medical screening of respirator users, consult the latest edition of the NIOSH Respirator Decision Logic [NIOSH 1987b] and the NIOSH Guide to Industrial Respiratory Protection [NIOSH 1987a].

PERSONAL PROTECTIVE EQUIPMENT

Workers should use appropriate personal protective clothing and equipment that must be carefully selected, used, and maintained to be effective in preventing skin contact with triphenyl amine. The selection of the appropriate personal protective equipment (PPE) (e.g., gloves, sleeves, encapsulating suits) should be based on the extent of the worker's potential exposure to triphenyl amine. There are no published reports on the resistance of various materials to permeation by triphenyl amine.

To evaluate the use of PPE materials with triphenyl amine, users should consult the best available performance data and manufacturers' recommendations. Significant differences have been demonstrated in the chemical resistance of generically similar PPE materials (e.g., butyl) produced by different manufacturers. In addition, the chemical resistance of a mixture may be significantly different from that of any of its neat components.

Any chemical-resistant clothing that is used should be periodically evaluated to determine its effectiveness in preventing dermal contact. Safety showers and eye wash stations should be located close to operations that involve triphenyl amine.

Splash-proof chemical safety goggles or face shields (20 to 30 cm long, minimum) should be worn during any operation in which a solvent, caustic, or other toxic substance may be splashed into the eyes.

In addition to the possible need for wearing protective outer apparel (e.g., aprons, encapsulating suits), workers should wear work uniforms, coveralls, or similar full-body coverings that are laundered each day. Employers should provide lockers or other closed areas to store work and street clothing separately. Employers should collect work clothing at the end of each work shift and provide for its laundering. Laundry personnel should be informed about the potential hazards of handling contaminated clothing and instructed about measures to minimize their health risk.

Protective clothing should be kept free of oil and grease and should be inspected and maintained regularly to preserve its effectiveness.

Protective clothing may interfere with the body's heat dissipation, especially during hot weather or during work in hot or poorly ventilated work environments.

REFERENCES

ACGIH [1991]. Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

ACGIH [1994]. 1994-1995 Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

CFR. Code of Federal regulations. Washington, DC: U.S. Government Printing Office, Office of the Federal Register.

Lewis RJ, ed. [1993]. Lewis condensed chemical dictionary. 12th ed. New York, NY: Van Nostrand Reinhold Company.

Lide DR [1993]. CRC handbook of chemistry and physics. 73rd ed. Boca Raton, FL: CRC Press, Inc.

Mickelsen RL, Hall RC [1987]. A breakthrough time comparison of nitrile and neoprene glove materials produced by different glove manufacturers. Am Ind Hyg Assoc J 48(11): 941-947.

Mickelsen RL, Hall RC, Chern RT, Myers JR [1991]. Evaluation of a simple weight-loss method for determining the permeation of organic liquids through rubber films. Am Ind Hyg Assoc J 52(10): 445-447.

NIOSH [1987a]. NIOSH guide to industrial respiratory protection. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 87-116.

NIOSH [1987b]. NIOSH respirator decision logic. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 87-108.

NIOSH [1991]. Registry of toxic effects of chemical substances: Triphenyl amine. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, Technical Information Branch.

NIOSH [1992]. Recommendations for occupational safety and health: Compendium of policy documents and statements. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 92-100.

NJDH [1986]. Hazardous substance fact sheet: Triphenyl amine. Trenton, NJ: New Jersey Department of Health.

NLM [1992]. Hazardous substances data bank: Triphenyl amine. Bethesda, MD: National Library of Medicine.

OSHA [1994]. Computerized information system. Washington, DC: U.S. Department of Labor, Occupational Safety and Health Administration.

Sax NI, Lewis RJ [1989]. Dangerous properties of industrial materials. 7th ed. New York, NY: Van Nostrand Reinhold Company.

Sittig M [1991]. Handbook of toxic and hazardous chemicals. 3rd ed. Park Ridge, NJ: Noyes Publications.

USC. United States code. Washington. DC: U.S. Government Printing Office.