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| On the Cover | An artist's rendering shows the moment before sperm and egg meet in conception. New data suggest that these moments may be fewer and farther in between due to the effects on fertility of exposure to myriad chemicals in the environment. The Focus (p. A644) examines the evidence that human reproductive effects are increasing as a result of modern life. image credit: Sebastian Kaulitzki/Shutterstock Purchase This Issue | |
Perspectives
Director's Perspective
p. A 630
Correspondence
p. A 632
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Environews
Forum
p. A 636
NIEHS News
p. A 640
Focus
p. A 644
Spheres of Influence
p. A 652
Innovations
p. A 656
Science Selections
p. A 660
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Commentaries & Reviews
Commentary
RISK ASSESSMENT | The Importance of Hormesis to Public Health
Ralph Cook and Edward J. Calabrese
p. 1631 [ Abstract ] [ Full ] [ PDF ]
Review
FETAL DEVELOPMENT | Exposures to Airborne Particulate Matter and Adverse Perinatal Outcomes: A Biologically Plausible Mechanistic Framework for Exploring Potential Effect Modification by Nutrition
Srimathi Kannan, Dawn P Misra, J. Timothy Dvonch, and Ambika Krishnakumar
p. 1636 [ Abstract ] [ Full ] [ PDF ]
Research
ENDOCRINE SYSTEM | Decreased Serum Free Testosterone in Workers Exposed to High Levels of Di-n-butyl Phthalate (DBP) and Di-2-ethylhexyl Phthalate (DEHP): A Cross-Sectional Study in China
Guowei Pan, Tomoyuki Hanaoka, Mariko Yoshimura, Shujuan Zhang, Ping Wang, Hiromasa Tsukino, Koichi Inoue, Hiroyuki Nakazawa, Shoichiro Tsugane, and Ken Takahashi
Also see Science Selections, p. A660
p. 1643 [ Abstract ] [ Full ] [ PDF ]
REPRODUCTIVE HEALTH | Serum Dioxin, Testosterone, and Subsequent Risk of Benign Prostatic Hyperplasia: A Prospective Cohort Study of Air Force Veterans
Amit Gupta, Norma Ketchum, Claus G. Roehrborn, Arnold Schecter, Corinne C. Aragaki, and Joel E. Michalek
p. 1649 [ Abstract ] [ Full ] [ PDF ]
METABOLISM | Expression of Xenobiotic Metabolizing Enzymes in Different Lung Compartments of Smokers and Nonsmokers
Thomas Thum, Veit J. Erpenbeck, Julia Moeller, Jens M. Hohlfeld, Norbert Krug, and Jürgen Borlak
p. 1655 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Cardiovascular Effects of Nickel in Ambient Air
Morton Lippmann, Kazuhiko Ito, Jing-Shiang Hwang, Polina Maciejczyk, and Lung-Chi Chen
p. 1662 [ Abstract ] [ Full ] [ PDF ]
REPRODUCTIVE HEALTH | Serum Dioxin-like Activity Is Associated with Reproductive Parameters in Young Men from the General Flemish Population
Willem Dhooge, Nicolas van Larebeke, Gudrun Koppen, Vera Nelen, Greet Schoeters, Robert Vlietinck, Jean-Marc Kaufman, and Frank Comhaire, for the Flemish Environment and Health Study Group
Also see Science Selections, p. A660
p. 1670 [ Abstract ] [ Full ] [ PDF ]
BIOMARKERS | Molecular Epidemiologic Evidence for Diabetogenic Effects of Dioxin Exposure in U.S. Air Force Veterans of the Vietnam War
Phillip Thomas Fujiyoshi, Joel Edmund Michalek, and Fumio Matsumura
p. 1677 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | An Intervention to Reduce Residential Insecticide Exposure during Pregnancy among an Inner-City Cohort
Megan K. Williams, Dana B. Barr, David E. Camann, Linda A. Cruz, Elizabeth J. Carlton, Mejico Borjas,, Andria Reyes, Dave Evans, Patrick L. Kinney, Ralph D. Whitehead Jr., Frederica P. Perera, Stephen Matsoanne, and Robin M. Whyatt
p. 1684 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Does Particulate Matter Modify the Association between Temperature and Cardiorespiratory Diseases?
Cizao Ren, Gail M. Williams, and Shilu Tong
p. 1690 [ Abstract ] [ Full ] [ PDF ]
NANOTECHNOLOGY | Distribution of Nanoparticles in the See-through Medaka (Oryzias latipes)
Shosaku Kashiwada
p. 1697 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Genotoxicants Target Distinct Molecular Networks in Neonatal Neurons
Glen E. Kisby, Antoinette Olivas, Melissa Standley, Xinfang Lu, Patrick Pattee, Jean O'Malley, Xiaorong Li, Juan Muniz, and Srinavasa R. Nagalla
Also see Science Selections, p. A661
p. 1703 [ Abstract ] [ Full ] [ PDF ]
Environmental Medicine
CIRCULATORY DISEASE | Grand Rounds: Outbreak of Hematologic Abnormalities in a Community of People Exposed to Leakage of Fire Extinguisher Gas
Shih-Hsiang Lo, Chang-Chuan Chan, Wei-Chin Chen, and Jung-Der Wang
p. 1713 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study
Sung Kyun Park, Joel Schwartz, Marc Weisskopf, David Sparrow, Pantel S. Vokonas, Robert O. Wright, Brent Coull, Huiling Nie, and Howard Hu
p. 1718 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Changes Induced by Exposure of the Human Lung to Glass Fiber-Reinforced Plastic
Carmelo Abbate, Concetto Giorgianni, Renato Brecciaroli, Giovanni Giacobbe, Chiara Costa, Vittorio Cavallari, Francesca Albiero, Stefania Catania, Maria Antonietta Tringali, Lucia Barbaro Martino, and Simona Abbate
p. 1725 [ Abstract ] [ Full ] [ PDF ]
Children's Health
NEURODEVELOPMENT | Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
Howard Hu, Martha María Téllez-Rojo, David Bellinger, Donald Smith, Adrienne S. Ettinger, Héctor Lamadrid-Figueroa, Joel Schwartz, Lourdes Schnaas, Adriana Mercado-García, and Mauricio Hernández-Avila
Also see Science Selections, p. A661
p. 1730 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Personal and Ambient Air Pollution is Associated with Increased Exhaled Nitric Oxide in Children with Asthma
Ralph J. Delfino, Norbert Staimer, Dan Gillen, Thomas Tjoa, Constantinos Sioutas, Kochy Fung, Steven C. George, and Michael T. Kleinman
p. 1736 [ Abstract ] [ Full ] [ PDF ]
FETAL DEVELOPMENT | International Studies of Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Fetal Growth
Hyunok Choi, Wieslaw Jedrychowski, John Spengler, David E. Camann, Robin M. Whyatt, Virginia Rauh, Wei-Yann Tsai, and Frederica P. Perera
p. 1744 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Gaseous Air Pollutants and Hospitalization for Respiratory Disease in the Neonatal Period
Robert E. Dales, Sabit Cakmak, and Marc Smith Doiron
p. 1751 [ Abstract ] [ Full ] [ PDF ]
Mini-monograph
BIOMONITORING | The Use of Biomonitoring Data in Exposure and Human Health Risk Assessments
Richard Albertini, Michael Bird, Nancy Doerrer, Larry Needham, Steven Robison, Linda Sheldon, and Harold Zenick
p. 1755 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | Potential Uses of Biomonitoring Data: A Case Study Using the Organophosphorus Pesticides Chlorpyrifos and Malathion
Dana B. Barr1 and Jürgen Angerer
p. 1763 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions
Linda S. Birnbaum1 and Elaine A. Cohen Hubal
p. 1770 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | The Applicability of Biomonitoring Data for Perfluorooctanesulfonate to the Environmental Public Health Continuum
John L. Butenhoff, Geary W. Olsen, and Andrea Pfahles-Hutchens
p. 1776 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | Integrating Biomonitoring Exposure Data into the Risk Assessment Process: Phthalates [Diethyl Phthalate and Di(2-ethylhexyl) Phthalate] as a Case Study
Antonia M. Calafat1 and Richard H. McKee
p. 1783 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | Biomarkers of Exposure: A Case Study with Inorganic Arsenic
Michael F. Hughes
p. 1790 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORING | Use of Biomonitoring Data to Evaluate Methyl Eugenol Exposure
Steven H. Robison1 and Dana B. Barr
p. 1797 [ Abstract ] [ Full ] [ PDF ]
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