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Water as Solvent for Metal-Mediated Carbon-Carbon Bond Formations

EPA Grant Number: R822668
Title: Water as Solvent for Metal-Mediated Carbon-Carbon Bond Formations
Investigators: Li, Chao-Jun
Institution: Tulane University of Louisiana
EPA Project Officer: Karn, Barbara
Project Period: August 1, 1997 through July 31, 2000
Project Amount: $200,000
RFA: Technology for a Sustainable Environment (1997)
Research Category: Pollution Prevention/Sustainable Development

Description:

This award is made to Dr. Chao-Jun Li of the Chemistry Department, Tulane University, for investigation of carbon-carbon bond formation in water. The award is in the Technology for Sustainable Environment component of the EPA/NCER Parnership for Environmental Research, and support is provided by the Organic Synthesis Program and the Office of Multidisciplinary Activities. Carbon-carbon bond forming reactions are typically carried out using metal catalysts in anhydrous organic solvents. In this study, the synthesis of various biologically important compounds and fine chemicals will be carried out in aqueous medium. The new method will be more efficient since the number of synthetic steps will be reduced. Additional research to attempt to make the reaction catalytic is also planned. Metal recovery and recycling from the aqueous stream will be used to ensure that the new process is environmentally beneficial. The specific reactions to be investigated include indium-promoted allylations, propargylation-allenylations, and aldol reactions. Large volumes of organic solvents are used in fine chemical and pharmaceutical industries for both reactions and product isolation. These solvents must be recycled or treated by costly methods rather than being expelled into the environment. By developing alternative synthetic methods using water as a solvent, the disposal problem for organic solvents can be reduced.

Publications and Presentations:

Publications have been submitted on this project: View all 88 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 40 journal articles for this project

Supplemental Keywords:

media, air, ambient air, atmosphere, water, drinking water, watersheds, groundwater pollution, green chemistry, sustainable development, alternatives, clean technologies, innovative technology, renewable, waste reduction, waste minimization, environmentally conscious manufacturing. , Sustainable Industry/Business, Scientific Discipline, RFA, Technology for Sustainable Environment, Sustainable Environment, Chemical Engineering, Environmental Chemistry, Economics and Business, anhydrous organic solvents, aqueous solvents, cleaner production, waste reduction, catalysts, green chemistry, carbon bond formation, waste minimization, environmentally benign solvents, metal recovery, recycling, alternative materials, pollution prevention

Progress and Final Reports:
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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