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2006 Progress Report: Carbon-Carbon Bond Formations in Water and Other Alternative Media

EPA Grant Number: R831662
Title: Carbon-Carbon Bond Formations in Water and Other Alternative Media
Investigators: Li, Chao-Jun
Institution: Tulane University
EPA Project Officer: Richards, April
Project Period: July 19, 2004 through July 18, 2007
Project Period Covered by this Report: July 19, 2005 through July 18, 2006
RFA: Technology for a Sustainable Environment (2003)
Research Category: Pollution Prevention/Sustainable Development

Description:

Objective:

The overall objective of this research is to explore novel chemical reactivities for more efficient and environmentally benign chemical synthesis in cleaner reaction media. In particular, the research is directed towards novel C-C bond formation reactions—the essence of chemical syntheses.

Progress Summary:

In the last funding period on this project, we have accomplished the following achievements:

  1. A one-step efficient tandem reaction to generate vinyl-indole derivatives catalyzed by gold was developed;
  2. An efficient direct coupling of C-H and C-H bond under neat conditions and without using a metal catalyst was developed;
  3. An efficient method for green separation of products from reactions in water was developed (to be published);
  4. A direct C-C bond formation using alkanes was developed (submitted for publication).

Future Activities:

During the no-cost extension period, we will further optimize the exciting results on the efficient functionalization of alkanes and the isolation technique for aqueous reactions.


Journal Articles on this Report: 3 Displayed | Download in RIS Format

Other project views: All 3 publications 3 publications in selected types All 3 journal articles

Type Citation Project Document Sources
Journal Article Li C-J, Chen L. Organic chemistry in water. Chemical Society Reviews 2006;35(1):68-82. R831662 (2006)
  • Full-text: Royal Society of Chemistry Full Text
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  • Abstract: Royal Society of Chemistry Abstract
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    • Journal Article Zhang Y, Li C-J. Highly efficient cross-dehydrogenative-coupling between ethers and active methlyene compounds. Angewandte Chemie International Edition 2006;45(12):1949-1952; German edition, 2006;118(12):1983-1986. R831662 (2006)
  • Abstract from PubMed
    • Journal Article Zhang Y, Donahue JP, Li C-J. Gold(III)-catalyzed double hydroamination of o-alkynylaniline with terminal alkynes leading to N-vinylindoles. Organic Letters 2007;9(4):627-630. R831662 (2006)
  • Abstract from PubMed
    • Supplemental Keywords:

    C-C Bond Formation, Cleaner Reaction Media, Cleaner Synthesis,

    Progress and Final Reports:
    Original Abstract

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