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Time: 11 a.m. to 12 noon each Friday, September through July Place: AFRRI Conference Room, unless otherwise indicated.
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Seminars are presented by AFRRI researchers and other members of the scientific community. To request to present a seminar or for more information about a specific seminar, use the button below to send e-mail to AFRRI's seminars administrator. While some seminars are open to the public, others are limited to specific audiences. Any exceptions to time, place, and admittance are noted with each item. We do not record or distribute information presented in our Seminar Program. However, where available, references to related information are provided with the seminar title.
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2009 seminar schedule
Friday, September 18: Thomas M. Seed, PhD, Principal Consultant, Tech Micro Services, Bethesda, MD: Canine model for chronic radiation health effects. Related information: CFU-GM colony enhancing activity in sera of dogs under acute and chronic gamma irradiation regimens. Acta Hematol., 71:189–197, 1984. Blood responses under chronic low daily dose gamma irradiation: I. Differential preclinical responses of irradiated male dogs in progression to either aplastic anemia or myeloproliferative disease. Leukemia Res., 13:1069–1084, 1989. Response of hemopoiesis in dogs to continuous low dose rate total body irradiation. Stem Cells, 13:261–267, 1995. Friday, September 11: Yufang Shi, PhD, Professor, Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ: NO links mesenchymal stem cells to immunosuppression. Related information: A new trick for an old drug: mTOR Inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma through inducing cell senescence. Commentary. Cancer Biol Ther., 7:397–398, 2008. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: Inhibition by an anti-osteopontin monoclonal antibody. J Immunol., 182:2485–2491, 2009. C/EBPbeta mediates synergistic upregulation of gene expression by interferon-gamma and tumor necrosis factor-alpha in bone marrow-derived mesenchymal stem cells. Stem Cells, 27:942–948, 2009. Friday, September 4: Merriline M. Satyamitra, PhD, Research Scientist (HMJF), Radiation Countermeasures Program, AFRRI: Evaluation of radiation countermeasures under NIAID-AFRRI inter agency agreement (IAA). Related Information: Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther., 5:1504–1510, 2006. Tracing radiation induced genomic instability in vivo in the haemopoietic cells from fetus to adult mouse. Br J Radiol., 78:928–933, 2005. Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. Int J Radiat Biol., 80:653–662, 2004. Friday, July 24: Lynnette Cary, PhD, Scientist (Henry M. Jackson Foundation), Radiation Countermeasures Program, AFRRI: Endothelial cells exposed to neutron/gamma mixed field radiation secrete factors involved in chemotaxis, angiogenesis, and cell survival. Related information: Epidermal growth factor receptor pathway substrate 8 (Eps8) is overexpressed in human pituitary tumors: Role in proliferation and survival. Endocrinology, 150:2064–2071, 2008. Bone morphogenetic protein and retinoic acid inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration and invasion. J. Endocrinology, 148:967–75, 2007. Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors. Cancer Gene Ther., 13:993–1001, 2006. Friday, July 17: Ian A. Gifford, PhD, Nuclear Engineer, AFRRI: Boron neutron capture therapy at the Maryland University Training Reactor (MUTR). Related information: Experimental validation of the new nanodosimetry-based cell survival model for mixed neutron and gamma-ray irradiation. Phys. Med. Biol., 52: 367–374, 2007. MUTR fuel bundle reactivity worth. Trans. Am. Nucl. Soc., 96: 407–410, 2007. A high LET neutron irradiation facility for biological samples at the MUTR. Trans. Am. Nucl. Soc., 94: 535–536, 2006. Friday, July 10: Juliann G. Kiang, PhD, Senior Principal Investigator, Combined Injury Program, AFRRI; Professor of Radiation Biology, Pharmacology, and Medicine, School of Medicine, USUHS: Wound trauma enhanced ionizing radiation-induced mortality: Roles of iNOS, cytokines, and bacterial infection. Related information: Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat. Shock., 30:411–946, 2008. Inhibition of inducible nitric oxide synthase protects human T cells from hypoxia-induced injury. Mol Pharmacol., 73:738–747, 2008. Androstenediol inhibits trauma-hemorrhage-induced increase in caspase-3 by downregulating inducible nitric oxide synthase pathway. J App Physiol., 102:933–941, 2007. Friday, June 26: Vijay K. Singh, PhD, Department of Radiation Biology, F. Edward Hebért School of Medicine USUHS; Radiation Countermeasure Program, AFRRI: Progress toward a radiation countermeasure that is effective when initiated days after irradiation. Related information: Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic, as a radiation countermeasure. Immunopharmacol. Immunotoxicol., 30: 271–90, 2008. Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression. Exp Mol Pathol., 84:178–188, 2007. Induction of cytokines by radioprotective tocopherol analogs. Expt Mol Pathol., 81:55–61, 2006. Friday, June 12 (noon–1 p.m.): Joseph Mattapallil, PhD, Assistant Professor, Department of Microbiology and Immunology, F. Edward Hebért School of Medicine, USUHS: Host modulation of acute HIV infection: lessons from the non-human primate model. Related information: Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections. J. Virol., 82:11589–98, 2008. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to SIV during acute infection. J. Immunol., 182:1439–48, 2009. High frequencies of resting CD4+ T cells containing integrated viral dna are found in rhesus macaques during acute lentivirus infection. Proc. Natl. Acad. Sci. USA, 106:8015–20, 2009. Friday, May 29: Yogendra Singh, PhD, Visiting Scientist, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md.; Scientist G, Institute of Genomics and Integrative Biology, Delhi, India: Protein kinases and phosphatases of mycobacterium tuberculosis. Related information: Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J, 275:6295–6308, 2008. Identification, characterization and activation mechanism of a tyrosine kinase of Bacillus anthracis. FEBS J, 275:6237–6247. Spo0B of Bacillus anthracis—a protein with pleiotropic functions. FEBS J, 273:2711–2721, 2008. Friday, May 15: Fung-Lung Chung, PhD, Professor, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC: Lung cancer chemprevention by isothiocyanates: From laboratory to human. Related information: The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res., 67:6409–6416, 2007. Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem., 283:22136–22146, 2008. Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem., 2009 Apr 1. [Epub ahead of print] Friday, May 8: Thomas B. Elliott, PhD, Research Microbiologist, Combined Injury Program, AFRRI: Susceptibility and cytokine responses to infections after ionizing irradiation. Related information: Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in 60Co-gamma-photon-irradiated and sham-irradiated mice. J Antimicrob Chemother., 56:1074–1080, 2005. Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without 60Co gamma-photon-irradiation. J Med Microbiol., 54:1157–1162, 2005. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol Cell Biochem., 272:29–34, 2005. Friday, May 1: Mukesh Verma, PhD, Chief, Methods and Technologies Branch, Program Director, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences. National Cancer Institute, NIH, Bethesda, Md.: Epigenetics approaches in cancer epidemiology. Related information: Diet, epigenetic events and cancer prevention. Nutrition Reviews, 66:S1–S6, 2008. Biomarkers for risk assessment in molecular epidemiology of cancer. Tech. Cancer Res. Treatment, 3:505–514, 2004. Proteomic analysis of the cancer cell mitochondria. Nature Reviews: Cancer 3, 789–795, 2003. Friday, April 24: Sanchita P. Ghosh, PhD, Research Investigator, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI), Bethesda, Md.: Mechanisms of radiation protection by gamma-tocotrienol. Related information: Radiation protection by a new chemical entity Ex-Rad™: efficacy and mechanisms. Radiation Res., 171:173–179, 2009. The role of cysteines and charged amino acids in extracellular loops of the human Ca²⁺ receptor in cell surface expression and receptor activation processes. Endocrinology, 145:3892–3903 (2004). Friday, April 10: Subrata Sinha, MD, PhD, Professor and Head, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India: Determinants of glial tumor heterogeneity: Molecular features and the microenvironment. Related information: Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis. BMC Cancer, 7:190, 2007. Frequent loss of heterozygosity encompassing the hMLH1 locus in low grade astrocytic tumors. J Neurooncol, 81:249–255, 2007. Identification and functional characterization of a novel unspliced transcript variant of HIC-1 in human cancer cells exposed to adverse growth conditions. Cancer Res, 66:10466–10477, 2006. Friday, April 3: Michael Graham Espey, PhD, Staff Scientist, Molecular & Clinical Nutrition Section, Digestive Disease Branch, National Institute of Diabetes Digestive and Kidney Diseases, NIH, Bethesda, Md.: Quercetin and glucose transport in the small intestine. Related information: Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. J Biol Chem., 283:18513–18521, 2008. Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Rad Biol Med., 45:578–584, 2008. Pharmacologic doses of ascorbate act as a pro-oxidant and decrease growth of aggressive tumor xenografts in mice. Proc Nat Acad Sci (USA), 105:11105–11109, 2008. Friday, March 27: William F. Blakely, PhD, Program Advisor, Biological Dosimetry, AFRRI: Early biodosimetry response: Recommendations for mass-casualty radiation accidents and terrorism. Related information: BiodosEPR-2006 Meeting: Acute dosimetry consensus committee recommendations on biodosimetry applications in events involving uses of radiation by terrorists and radiation accidents. Radiation Measurements, 42:972–996, 2007. Genistein-induced alterations of radiation-responsive gene expression. Radiation Measurements, 42:1152–1157, 2007. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements, 42:1158–1163, 2007. Friday, March 20: Gregory L. King, PhD, Research Physiologist, Radiation Infection Treatment Program, AFRRI: The rat as an animal model for radiation-induced GI mucositis. Related information: Early-expression and non-invasive biomarkers of acute radiation syndrome, NATO HFM-099/RTG-099, June 2007, Annual Meeting, Brno, Czech Republic. Sublethal gamma-radiation decreases resistance of mice to oral Shigella sonnei challenge. Microbial Ecol Health Dis., 14: 179–90, 2002. Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield. Mil Med., 167:95–7, 2002. Friday, March 13: John F. Kalinich, PhD, Program Advisor, Internal Contamination and Metal Toxicity Program, AFRRI: Determination of radiation exposure using urinary biomarkers. Related information: Urinary and serum metal levels as indicators of embedded tungsten alloy fragments. Mil Med., 173:754–758, 2008. Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ Health Perspect., 113:729–34, 2005. Depleted uranium-uranyl chloride induces apoptosis in mouse J774 macrophages. Toxicology, 179:105–14, 2002. Friday, March 6: Michael R. Landauer, PhD, Research Toxicologist, AFRRI: Radioprotection by genistein: mechanisms of action. Related information: Genistein induces radioprotection by hematopoietic stem cell quiescence. Int J Radiat Biol., 84:713–726, 2008. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res (Tokyo), 49:361–72, 2008. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol., 83: 141–151, 2007. Friday, February 27: G. David Ledney, PhD, Research Biologist, Radiation Combined Injury Program, AFRRI: Combined injury: treatment and radiation dose determination challenges. Related information: Retrospective analyses of serum lipids and lipoproteins and severity of disease in 60Co-irradiated Sus scrofa domestica and Macaca mulatta. Comp. Med., 57:298–304, 2007 Medical countermeasures for radiation combined injury: radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26–27, 2007. Radiat. Res., 169: 712–721, 2008. Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol., 46:329–35, 2006. Friday, February 20: K.S. Kumar, PhD, Research Chemist, Radiation Countermeasures, AFRRI: Radiation countermeasure studies with tocols. Related information: Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sci., 78:2099–104, 2006. Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol 81: 55–61, 2006. High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines. J Radiat Res (Tokyo), 43:361–70, 2002. Friday, February 13: Pataje G.S. Prasanna, PhD, Research Biologist, AFRRI: Cytogenetic biodosimetry at the Armed Forces Radiobiology Research Institute. Related information: Interlaboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events. Radiat.. Res., 169:551–560, 2008. Sample tracking in an automated cytogenetic biodosimetry laboratory for radiation mass casualties. Radiat Meas. 42:1119–1124, 2007. Early-response biological dosimetry—recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 89:494–504, 2005. Friday, February 6: Venkataraman Srinivasan, PhD, Research Biologist, Radiation Countermeasure Program, AFRRI: Delta tocotrienol as a radiation countermeasure. Related information: Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol., 30:271–290, 2008. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxident gamma-tocotrienol. Life Sciences, 78:2099–2104, 2006. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol., 23:379–385, 2003. Friday, January 30: Anu Puri, PhD, Research Biologist, CCR Nanobiology Program, NIH, NCI-Frederick, Frederick, Md.: Lipid-based nanoparticles for sustained, targeted, and localized delivery of cancer therapeutics. Related information: Glycoside analogs of beta-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry. Antiviral Res., 80:54–61, 2008. Restricted lateral mobility of plasma membrane CD4 impairs HIV-1 envelope glycoprotein mediated fusion. Mol Membr Biol., 25:83–94, 2008. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol., 32:1119–1123, 2008. Friday, January 23: Richard N. Kolesnick, MD, Associate Member, Molecular Pharmacology and Therapeutics Program, Sloan-Kettering Institute, N.Y.: Radiation-induced GI and bone marrow damage: two events or three? Related information: Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Oncol Biol Phys., 73:6–8, 2009. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of Caenorhabditis elegans. Science, 322:110–115, 2008. Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. Proc Natl Acad Sci USA, 105:7670–7675, 2008. Friday, January 16: Barrett N. Fountos, MS, Program Manager/Health Scientist, Office of International Health Studies, U.S. Department of Energy (DOE), Germantown, Md.: History and relevance of the Russian health studies program. Related information: Letter to the Editor of Health Physics concerning the Department of Energy’s Russian Health Studies Program. Health Physics, 93:187–189, 2007.
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