Research Topic: Environmental & Occupational Exposures / Depleted Uranium & Other Heavy Metals

On-going Research Projects:
Carcinogenicity of Embedded Tungsten Alloys in Mice
This project proposes to determine if alloys tungsten/nickel/cobalt and tungsten/nickel/iron cause cancer in mice.

Novel Pharmacological Approaches for Treatment of Neurotoxicity Induced by Chronic Exposure to Depleted Uranium
This animal study will look at potential treatments for neurotoxicity caused by chronic exposure to depleted uranium.


Completed Research Projects:
Blood-Brain Barrier Transport of Uranium
This study in animals evaluated how uranium in the blood may be transported into the brain to help determine whether veterans with embedded depleted uranium fragments are at risk for developing nervous system toxicity as a result of uranium accumulation in the brain.

Carcinogenic Potential of Depleted Uranium and Tungsten Alloys (see also DoD-130)
This animal study looked at whether or not embedded fragments of depleted uranium (DU) cause changes in cells of the body.

Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloys in Rodents
This study in animals evaluated the potential for embedded depleted uranium fragments to cause cancer and changes in the immune system, in order to help determine whether or not long-term exposures are harmful.

Carcinogenicity of Depleted Uranium Fragments
This animal study tested the effects of tissue-embedded depleted uranium fragments.

Characterization of the Reproductive Toxicity of Depleted Uranium
This animal project tested the effects of depleted uranium on reproduction.

Depleted Uranium Fragment Carcinogenicity: Extrapolation of Findings in Rodents to Man
This animal study evaluated the effects of implanted depleted uranium.

Evaluation of the Health Risks of Embedded Depleted Uranium (DU) Shrapnel on Pregnancy and Offspring Development
This project developed an animal model to examine the toxicological and behavorial effects of depleted uranium on female rats.

Evaluation of the Health Risks of Embedded Depleted Uranium Shrapnel During Pregnancy and Offspring Development
This study looked at whether or not embedded fragments of depleted uranium (DU) alter the ability of female animals to conceive and produce healthy offspring.

Health Risk Assessment of Embedded Depleted Uranium: Behavior, Physiology, Histology, and Biokinetic Modeling
This animal study tested the effects of embedded depleted uranium fragments.

Immunotoxicity of Depleted Uranium and Heavy Metal Tungsten Alloys (see also DoD-130)
This animal study looked at whether or not embedded fragments of depleted uranium (DU) caused the immune system to not work properly.

Inhalation of Uranium Oxide Aerosol: CNS Deposition, Neurotoxicity, and Role in Gulf War Illness
This animal study evaluated the potential for inhaled uranium oxide (from combustion of depleted uranium) to enter the brain through the nose and cause nervous system damage.

Multifactorial Assessment of Depleted Uranium Neurotoxicity
This study in animals was designed to evaluate the uptake, distribution, and retention of depleted uranium in the brain in the presence and absence of stress, and to examine changes following short and long-term exposure, in order to better understand the potential nervous system toxicity of uranium.

Neurotoxicity from Chronic Exposure to Depleted Uranium
This animal study tested the effects of chronic exposure to depleted uranium on brain function.

Preconceptional Paternal Exposure to Embedded Depleted Uranium Fragments: Transmission of Genetic Damage to Offspring
This animal study investigated if male mice with embedded fragments of depleted uranium transmitted genetic damage to their offspring.


Reports & Publications

The link(s) below provide access to all available reports done by, or sponsored by, the U.S. government and a listing of articles from peer-reviewed medical and scientific journals related to the Research Topic: Environmental & Occupational Exposures and Subtopic: Depleted Uranium & Other Heavy Metals .

Deployment Health Reports
Government Reports
Medical Research Publications
Medical & Scientific Journal Articles

Fact Sheets

The following fact sheets are from the Deployment Health and Family Readiness Library specific to Research Topic: Environmental & Occupational Exposures and Sub-Research Topic: Depleted Uranium & Other Heavy Metals.

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DeployMed ResearchLINK was last updated on 2008-10-03