The following text is from UNDERSTANDING OUR
GENETIC INHERITANCE: THE U.S. HUMAN GENOME PROJECT, The
First Five Years: Fiscal Years 1991-1995, published
April 1990. DOE/ER-0452P, NIH Publication No. 90-1590.
The Human Genome
Project is a worldwide research effort with the goal of
analyzing the structure of human DNA and determining the
location of the estimated 100,000 human genes. In
parallel with this effort, the DNA of a set of model
organisms will be studied to provide the comparative
information necessary for understanding the functioning
of the human genome. The information generated by the
human genome project is expected to be the source book
for biomedical science in the 21st century and will be of
immense benefit to the field of medicine. It will help us
to understand and eventually treat many of the more than
4000 genetic diseases that afflict mankind, as well as
the many multifactorial diseases in which genetic
predisposition plays an important role.
A centrally coordinated project focused on specific
objectives is believed to be the most efficient and least
expensive way of obtaining this information. In the
course of the project much new technology will be
developed to facilitate a broad range of biological and
biomedical research, bring down the cost of many
experiments, and find application in numerous other
fields. The basic data produced will be collected in
electronic databases that will make the information
readily accessible in convenient form to all who need it.
This report describes the plans for the U.S. human
genome project and updates those originally prepared by
the Office of Technology Assessment (OTA) and the
National Research Council (NRC) in 1988. In the
intervening two years, improvements in technology for
almost every aspect of genomics research have taken
place. As a result, more specific goals can now be set
for the project.
Five-year goals have been identified for the following
areas, which together encompass the human genome project:
- Mapping and Sequencing the Human Genome
- Mapping and Sequencing the Genomes of Model
Organisms
- Data Collection and Distribution
- Ethical, Legal, and Social Considerations
- Research Training
- Technology Development
- Technology Transfer
This plan sets out specific scientific goals to be
achieved in the first five years together with the
rationale for each goal. The specific goals will be
reviewed annually and updated as further advances in the
underlying technology occur.
The plan presented here was prepared jointly by the
National Institutes of Health (NIH) and the Department of
Energy (DOE), the two agencies that have received funding
earmarked for the human genome project. Over the past two
years, these agencies have developed a highly synergistic
and well-integrated approach to carrying out this
Project, as evidenced by the adoption of this common
plan. The National Institutes of Health has a natural
interest in the Human Genome Project in view of its long
history of supporting research in genetics and molecular
biology as an integral part of its mission to improve the
health of all Americans. The Department of Energy has a
long-standing program of genetic research directed at
improving the ability to assess the effects of radiation
and energy-related chemicals on human health.
To achieve the scientific goals set out in this
report, a number of administrative measures have been put
in place. In addition, a newsletter, an electronic
bulletin board, a comprehensive administrative database,
and other communications tools are being set up to
facilitate communication and tracking of progress.
Research centers will be established to promote the
collaboration of investigators from diverse disciplines
on a major task of the genome program. DOE has already
established three large centers in its National
Laboratories and NIH will establish 10 to 20 additional
centers over the next five years. The centers will become
foci for collaboration with investigators at other
locations and with industrial organizations that want to
develop applications of the research results, thereby
creating networks of interrelated projects.
Meetings and workshops will be organized to bring
together investigators with common research objectives
and to encourage collaboration, exchange of materials and
use of common starting materials or protocols wherever
these are appropriate. It is expected that mapping and
sequencing groups will coalesce around individual human
chromosomes or around particular model organisms.
NIH and DOE will continue their synergistic working
relationship and will also interact closely with other
interested agencies, as well as with genome mapping
programs in other countries as they get organized. Close
ties with industry and with the medical community have
been established, and will continue to be encouraged, to
ensure efficient technology transfer. The private sector
is involved in this project at all levels from
participation in the advisory committees to receipt of
grants and contracts.
The overall budget needs for the effort are still
anticipated to be the same as those identified by the OTA
and the NRC, namely about $200 million per year for
approximately 15 years. Fiscal years 1988 to 1990 have
been a period for getting organized and getting research
under way. The five-year goals specified in this plan are
for the period FY 1991 through FY 1995 and assume the
program will rapidly reach the level of funding specified
above.
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