![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081106013612im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
2006 Progress Report: Johns Hopkins Particulate Matter Research Center
EPA Grant Number: R832417Center: Johns Hopkins Particulate Matter Research Center
Center Director: Samet, Jonathan M.
Title: Johns Hopkins Particulate Matter Research Center
Investigators: Samet, Jonathan M. , Bell, Michelle L. , Breyss, Patrick , DeCastro, Rey , Dominici, Francesca , Garcia, Joe , Geyh, Alison , Irizarry, Rafael , Natarajan, Viswanathan , Peng, Roger D. , Spannhake, Ernst , Zeger, Scott L.
Institution: Johns Hopkins University , University of Chicago , Yale University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 2005 through September 30, 2010
Project Period Covered by this Report: October 1, 2005 through September 30, 2006
Project Amount: $7,993,275
RFA: Particulate Matter Research Centers (2004)
Research Category: Particulate Matter
Description:
Objective:This Progress Report covers the first year of funding of the Johns Hopkins Particulate Matter Research Center. The Center has the overall goal of identifying the characteristics of airborne particles that determine their toxicity and hence the risk posed to human health. This goal corresponds largely to Topic 5 of the ten research issues advanced by the National Research Council’s Committee on Research Priorities for Airborne Particles. To accomplish this goal, the Johns Hopkins Center brings together a multi-disciplinary team with expertise in epidemiology, biostatistics, exposure assessment and air pollution monitoring, cell biology, and toxicology. It includes three research projects: 1) Estimation of the Risk to Human Health of PM and PM Components; 2) Particulate Matter Characterization and Exposure Assessment; and 3) Toxicity of PM, along with supporting cores.
Progress Summary:During this first year of funding, administrative infrastructure needed for the Center has been put into place, the Scientific Advisory Committee has been appointed and held its first meeting, and the initial Quality Management Plan (QMP) has been developed and submitted to the U.S. Environmental Protection Agency for review and comment. The members of the Scientific Advisory Committee cover the broad set of scientific disciplines relevant to the goals of the Center. Each of the research projects has made substantial progress and two investigator retreats have been held to assure that the needed interdisciplinary interactions are taking place.
Separate reports are available for each of the projects. In each report, we discuss: 1) the research performed and results generated in this first year, and 2) challenges encountered in the research and proposed actions.
Journal Articles: 18 Displayed | Download in RIS Format
| Other center views: | All 21 publications | 18 publications in selected types | All 18 journal articles |
| Type | Citation | ||
|---|---|---|---|
|
|
Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environmental Health Perspectives 2006;114(4):532-536. |
R832417C001 (2006) R832417C001 (2007) |
|
|
|
Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
|
|
|
Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. |
R832417C001 (2007) R832417C001 (2008) |
|
|
|
Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. |
R832417C001 (2008) |
|
|
|
Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. Journal of the American Medical Association 2006;295(10):1127-1134. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R830548 (2005) |
|
|
|
Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. |
R832417C001 (2008) |
|
|
|
Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to ‘‘heterogeneity of particulate matter health risks.’’ American Journal of Epidemiology 2007;166(8):892-893. |
R832417C001 (2008) |
|
|
|
Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. |
R832417C001 (2007) R832417C001 (2008) |
|
|
|
Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. |
R832417C001 (2008) |
|
|
|
Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality:a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. |
R832417C001 (2008) |
|
|
|
Janes H, Dominici F, Zeger SL. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428. |
R832417C001 (2008) |
|
|
|
Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality:an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
|
|
|
Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society: Series A (Statistics in Society) 2006;169(2):179-203. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
|
|
|
Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
|
|
|
Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. Journal of the American Medical Association 2008;299(18):2172-2179. |
R832417C001 (2008) |
|
|
|
Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
|
|
|
Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health, Part A: Current Issues 2007;70(3-4):311-315. |
R832417C001 (2008) |
|
|
|
Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwarz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health 2007;70(3-4):311-315. |
R832417C001 (2007) R831861 (2005) |
|
, Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Risk Assessments, Health Risk Assessment, Physical Processes, particulate matter, Environmental Chemistry, epidemiology, respiratory impact, cardiovascular disease, cardiovascular vulnerability, chemical characteristics, ultrafine particulate matter, particulate matter components, cardiopulmonary mechanisms, cardiotoxicity, cardiopulmonary responses, human health risk, oxidative stress, pulmonary toxicity, particle exposure, pariculate matter, human health effects, toxicology, ambient particle health effects, endothelial function, atmospheric particulate matter, exposure, airborne particulate matter, lung epithelial cells, human exposure, PM, particulate exposure
Progress and Final Reports:
Original Abstract
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832417C001 Estimation of the Risks to Human Health of PM and PM Components
R832417C002 PM Characterization and Exposure Assessment (Project 2)
R832417C003 Biological Assessment of the Toxicity of PM and PM Components