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Johns Hopkins Particulate Matter Research Center
EPA Grant Number: R832417Center: Johns Hopkins Particulate Matter Research Center
Center Director: Samet, Jonathan M.
Title: Johns Hopkins Particulate Matter Research Center
Investigators: Samet, Jonathan M. , Breyss, Patrick , Chillrod, Steven , Dominici, Francesca , Garcia, Joe , Ondov, John M.
Current Investigators: Samet, Jonathan M. , Bell, Michelle L. , Breyss, Patrick , DeCastro, Rey , Dominici, Francesca , Garcia, Joe , Geyh, Alison , Irizarry, Rafael , Natarajan, Viswanathan , Peng, Roger D. , Spannhake, Ernst , Zeger, Scott L.
Institution: Johns Hopkins University , Columbia University (Lamont Doherty Earth Observatory) (JHPMRC) , University of Chicago , University of Maryland , Yale University
Current Institution: Johns Hopkins University , University of Chicago , Yale University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 2005 through September 30, 2010
Project Amount: $7,993,275
RFA: Particulate Matter Research Centers (2004)
Research Category: Particulate Matter
Description:
Objective:The Johns Hopkins PM Research Center brings together a multidisciplinary research team: biostatisticians, epidemiologists, exposure assessors, lung biologists and respiratory toxicologists, pulmonary clinicians, and atmospheric scientists to address the most critical gap in current understanding of health and particulate matter (PM) the physical and chemical characteristics that determine risk to human health. The Center's conceptual foundation lies in mapping health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then using the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.
Approach:The Center's three-phase agenda builds progressively from mapping the health risks in the first phase. During this first phase, we will also explore patterns of PM characteristics across the United States using existing data; we will develop protocols for detailed PM monitoring and collection of sufficient materials for bioassays; adapt existing in vitro and in vivo bioassays for assessing the comparative toxicity of the PM samples; and develop relevant microarray approaches. In the second phase, we will monitor and collect PM from 10 sites, selected from the higher and lower extremes of the effects of PM on human health; we will then assess the comparative toxicity of the PM samples in the bioassay battery. The third phase is likely to involve assessment of risks of more toxic particles in susceptible populations, source-related relative risk characterization, exposure assessment studies, and more focused studies of mechanisms of injury by these particles. The Center will have three discipline-based Research Projects and two scientific cores, the Data Base Core and the PM Collection, Sampling & Analysis Core. The Administrative Core will be the focal point for interdisciplinary interactions.
Expected Results:The Center will map health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then use the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.
Journal Articles: 18 Displayed | Download in RIS Format
| Other center views: | All 21 publications | 18 publications in selected types | All 18 journal articles |
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Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environmental Health Perspectives 2006;114(4):532-536. |
R832417C001 (2006) R832417C001 (2007) |
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Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
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Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. |
R832417C001 (2007) R832417C001 (2008) |
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Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. |
R832417C001 (2008) |
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Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. Journal of the American Medical Association 2006;295(10):1127-1134. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R830548 (2005) |
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Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. |
R832417C001 (2008) |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to ‘‘heterogeneity of particulate matter health risks.’’ American Journal of Epidemiology 2007;166(8):892-893. |
R832417C001 (2008) |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. |
R832417C001 (2007) R832417C001 (2008) |
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Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. |
R832417C001 (2008) |
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Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality:a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. |
R832417C001 (2008) |
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Janes H, Dominici F, Zeger SL. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428. |
R832417C001 (2008) |
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Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality:an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
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Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society: Series A (Statistics in Society) 2006;169(2):179-203. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
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Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
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Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. Journal of the American Medical Association 2008;299(18):2172-2179. |
R832417C001 (2008) |
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Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. |
R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) |
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Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health, Part A: Current Issues 2007;70(3-4):311-315. |
R832417C001 (2008) |
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Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwarz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health 2007;70(3-4):311-315. |
R832417C001 (2007) R831861 (2005) |
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PM Components, susceptible populations, human health risks, toxicological and genomic bioassays,
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Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Risk Assessments, Health Risk Assessment, Physical Processes, particulate matter, Environmental Chemistry, epidemiology, respiratory impact, cardiovascular disease, cardiovascular vulnerability, chemical characteristics, ultrafine particulate matter, particulate matter components, cardiopulmonary mechanisms, cardiotoxicity, cardiopulmonary responses, human health risk, oxidative stress, pulmonary toxicity, particle exposure, pariculate matter, human health effects, toxicology, ambient particle health effects, endothelial function, atmospheric particulate matter, exposure, airborne particulate matter, lung epithelial cells, human exposure, PM, particulate exposure
Progress and Final Reports:
2006 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832417C001 Estimation of the Risks to Human Health of PM and PM Components
R832417C002 PM Characterization and Exposure Assessment (Project 2)
R832417C003 Biological Assessment of the Toxicity of PM and PM Components