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2002 Progress Report: Health Effects Research Core

EPA Grant Number: R827355C007
Subproject: this is subproject number 007 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Health Effects Research Core
Investigators: Kaufman, Joel D. , Gill, Edward , Koenig, Jane Q. , Sullivan, Jeff , Trenga, Carol
Institution: University of Washington
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2004
Project Period Covered by this Report: June 1, 2001 through May 31, 2002
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter

Description:

Objective:

To provide epidemiological and medical consultation for all Center activities and investigators. A further goal is to acquire and maintain appropriate health testing equipment for evaluating respiratory and cardiovascular health outcomes.

Progress Summary:

The Health Core continues to support other research projects in the Center. During Year 4, we took a principal role in the design and execution of a study of the effects of agricultural burning in young asthmatics in Eastern Washington. The Health Core also supported development of testable hypotheses and protocols for studies in the new controlled exposure facility.

Future Activities:

During Year 4 of the project, the Health Core took the lead on analysis of heart rate variability (HRV) and systemic markers of inflammation and thrombosis in serum. The core has acquired new equipment for assessment of exhaled nitric oxide in human subjects for ongoing studies. During the upcoming year we will finalize and submit manuscripts from the panel study related to Heart Rate Variability, systemic markers of inflammation and thrombosis in serum, and pediatric lung function. We will complete analysis of the results of the agricultural burning health effects study. We will continue to support development of protocols in the new controlled exposure facility.

Supplemental Keywords:

air pollution, particulates, particulate matter, PM, PM2.5, PM10, health effects, heart rate variability, HRV, systemic markers of inflammation, systemic markers of thrombosis in serum, Health Core. , Air, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Toxicology, Risk Assessments, Northwest, Health Risk Assessment, Epidemiology, Air Pollution Effects, air toxics, Atmospheric Sciences, Biochemistry, particulate matter, Environmental Chemistry, State, aerosols, exposure assessment, California (CA), exposure and effects, environmental hazard exposures, ambient air quality, cardiovascular disease, health effects, inhalation, mortality, epidemelogy, air quality, cardiopulmonary response, hazardous air pollutants, atmospheric aerosols, cardiopulmonary responses, human health risk, particle exposure, toxics, mortality studies, acute cardiovascular effects, air pollutants, biostatistics, human health effects, particulates, sensitive populations, ambient particle health effects, air pollution, atmospheric chemistry, exposure, human susceptibility, ambient aerosol, asthma, health risks, human exposure, Human Health Risk Assessment, morbidity
Relevant Websites:

http://depts.washington.edu/pmcenter/ exit EPA

Progress and Final Reports:
Original Abstract


Main Center Abstract and Reports:
R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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