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1999 Progress Report: Assessing Deposition of Ambient Particles in the Lung
EPA Grant Number: R827353C009Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Assessing Deposition of Ambient Particles in the Lung
Investigators: Tsuda, Akira
Current Investigators: Godleski, John J. , Tsuda, Akira
Institution: Harvard University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:This project is one of three under Theme III: Biological Mechanisms and Dosimetry of our proposal. The main objective of this project is to use in situ continuous respiratory and total deposition measurements to develop a new regional deposition. This project was intended to address Particulate Matter Research Topic 6 identified by the National Research Council (NRC)-Dosimetry. Progress Summary:
In this project, we have developed the capability to assess deposition of CAPs in awake dogs. These studies focus on using ambient particles to assess deposition in relationship to particle size, mass, and number. Hardware needed to be designed and implemented specifically for these studies. In addition, a number of modifications in existing equipment were needed to adapt these for use with the ambient particle concentrator. These have all been completed and tested. Deposition studies have been carried out on one pair of dogs. These went well and data analysis is in progress. We expect to present our initial findings in this area at the advisory council meeting. Future Activities:
In the coming year, we expect to place considerable emphasis on our deposition studies. We expect to use the fine concentrator and define deposition of particles under a number of different atmospheric, seasonal, and weather pattern conditions. The relationship of mass, particle size, and compositional factors will be studied in relationship to deposition of ambient particles. In addition, we expect to be able to use our collected data in relationship to deposition models developed in our laboratory. Journal Articles:
No journal articles submitted with this report: View all 4 publications for this subproject
Supplemental Keywords:particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring. , Air, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Biology, indoor air, Risk Assessments, genetic susceptability, Epidemiology, air toxics, Environmental Microbiology, particulate matter, Environmental Chemistry, ambient measurement methods, cardiopulmonary, risk assessment, exposure and effects, heart rate, COPD, ambient air quality, cardiovascular disease, health effects, indoor air quality, inhalation, developmental effects, epidemelogy, animal inhalation study, respiratory disease, inhalation toxicology, air quality, ambient air, cardiopulmonary response, indoor exposure, molecular epidemiology, cardiopulmonary responses, human health risk, interindividual variability, monitoring, genetic susceptibility, particle exposure, toxics, air pollutants, human health effects, particulates, respiratory, sensitive populations, ambient particle health effects, air pollution, ambient monitoring, inhaled, metals, stratospheric ozone, ambient air monitoring, chemical exposure, dosimetry, exposure, inhaled particles, pulmonary, human health, human susceptibility, biological mechanism , health risks, human exposure, Human Health Risk Assessment, PM, pulmonary disease
Relevant Websites:
http://www.hsph.harvard.edu/epacenter/homeframe.htm
Progress and Final Reports:
Original Abstract
2000 Progress Report
2001 Progress Report
2002 Progress Report
Final Report
Main Center Abstract and Reports:
R827353 EPA Harvard Center for Ambient Particle Health Effects
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological
Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards
Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to
Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate
Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition,
and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters,
Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core