International Lymphoma Epidemiology
Consortium
Supplementals
Morton LM, Turner JJ, Cerhan JR, Linet MS, Treseler PA, Clarke CA, Jack A,
Cozen W, Maynadié M, Spinelli JJ, Seniori Costantini A, Rüdiger T, Scarpa A,
Zheng T, Weisenburger DD. Proposed
classification of lymphoid neoplasms for epidemiologic research from the
International Lymphoma Epidemiology Consortium (InterLymph). Blood.
2007 Jul 15; 110(2): 695-708.
Summary: Recent evidence suggests that there is etiologic heterogeneity among
the various subtypes of lymphoid neoplasms. However, epidemiologic analyses
by disease subtype have proven challenging due to the numerous clinical and
pathological schemes used to classify lymphomas and lymphoid leukemias over
the last several decades. On behalf of the International Lymphoma Epidemiology
Consortium (InterLymph) Pathology Working Group, we present a proposed nested
classification of lymphoid neoplasms to facilitate the analysis of lymphoid
neoplasm subtypes in epidemiologic research. The proposed classification is
based on the World Health Organization classification of lymphoid neoplasms
and the International Classification of Diseases-Oncology, third edition (ICD-O-3).
We also provide a translation into the proposed classification from previous
classifications, including the Working Formulation, Revised European-American
Lymphoma (REAL) classification, and ICD-O-2. We recommend that epidemiologic
studies include analyses by lymphoma subtype to the most detailed extent allowable
by sample size. The standardization of groupings for epidemiologic research
of lymphoma subtypes is essential for comparing subtype-specific reports in
the literature, harmonizing cases within a single study diagnosed using different
systems, as well as combining data from multiple studies for the purpose of
pooled analysis or meta-analysis, and will likely prove to be critical for
elucidating etiologies of the various lymphoid neoplasms.
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