T cell clonotypic correlates of virus control in SIV infection
 


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Air date: Wednesday, June 10, 2009, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Immunology
Description: Dr. Douek is a recognized leader in the field of human immunology. His laboratory, the Human Immunology Section, studies the processes that determine the course of human diseases in which the immune system, particularly its T cell arm, plays a central role in their pathogenesis and outcome. He aims to use the knowledge gained to initiate clinical studies of new therapeutic and vaccine approaches. His overriding philosophy is to address questions directly in humans and non-human primates, with an emphasis on the derivation of the basic mechanisms that underlie disease processes. Currently, the main focus of the lab is the pathogenesis of HIV infection. By studying interactions of HIV-specific T cells in HIV disease and after vaccination against HIV, Dr. Douek's aim is to establish correlates of effective and protective immunity, which in turn will open lines of further inquiry for researchers in developing strategies using T-cell immunity to fight HIV infection. By studying the mechanisms underlying HIV pathogenesis and immune reconstitution after therapy, his goal is to understand how HIV causes disease and how recovery from HIV disease can be enhanced. Together, these approaches address both prevention and treatment of HIV disease in humans. In 2007 Dr. Douek was given the World AIDS Day Award.

For more information, visit
The Immunology Interest Group
Author: Dr. Daniel Douek, Chief, Human Immunology Section, Vaccine Research Center, NIAID, NIH
Runtime: 75 minutes
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CIT File ID: 15163
CIT Live ID: 7463
Permanent link: http://videocast.nih.gov/launch.asp?15163