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Figure 2. Potential Harms of Hormone Replacement Therapy. Analytic Framework 2

Analytic Framework 2 begins with 'Postmenopausal women' on the left. A line labeled 'HRT *estrogen, *estrogen/progestin' leads from 'Postmenopausal women' and divides into numbered arrows, each representing a key question: 1. Venous thromboembolism (DVT/PE); 2. Breast cancer incidence; 4. Endometrial cancer; 5. Cholecystitis. An arrow labeled 3 leads from 2 to a box that reads 'Increase in morbidity and mortality'; dotted lines from 1, 4, and 5 also lead to this box.

Note: DVT indicates deep-vein thrombosis; PE, pulmonary embolus.

Select for Analytic Framework 1 for potential benefits.

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