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Neglected Tropical Diseases

Neglected tropical diseases (NTDs) such as dengue, lymphatic filariasis, trachoma, and leishmaniasis take a tremendous toll on global health. The World Health Organization (WHO) estimates that over one billion people—approximately one-sixth of the world's population—suffer from at least one NTD.

NTDs are called "neglected" because they generally afflict the world's poor and historically have not received as much attention as other diseases. NTDs tend to thrive in developing regions of the world, where water quality, sanitation, and access to health care are substandard. However, some of these diseases also are found in areas of the United States with high rates of poverty.

While NTDs rarely lead to death, they can cause significant disability that persists for a lifetime. They can cause fatigue, blindness, and disfigurement. Sufferers miss school, are unable to work, or are too embarrassed to seek medical care. By diminishing quality of life and opportunities to succeed, NTDs can reinforce the cycle of poverty among the world's disadvantaged populations.

one stage of the life cycle of Brugia malayi diagram
View an illustration of the life cycle of Brugia malayi, one of the parasitic worms that cause lymphatic filariasis.

Volunteer for Clinical Studies
Volunteer for clinical studies related to neglected tropical diseases on ClinicalTrials.gov.

NIAID Research Targets NTDs

NIAID has a robust program of research devoted to better understanding, preventing, and treating NTDs. Studies conducted and supported by NIAID have led to important new discoveries about the microbes that cause NTDs, the identification of targets for potential new drugs and vaccines, and the development of strategies for controlling the organisms that transmit NTD-causing agents to humans.

Read more about NIAID's Role in NTD Research.

Highlights

  • Examples of NTDs
  • Recent Scientific Findings
  • NTD Workshop Summary: Identifying Research Gaps and Opportunities (PDF)
  • NIAID Researchers Take Aim at Filarial Infections
  • News Releases

    Genomes of Parasitic Flatworms Decoded—July 15, 2009

    New Understanding of Dengue Virus Points Way to Possible Therapies for Dengue Fever—Apr. 22, 2009

    Seizures Following Parasitic Infection Associated with Brain Swelling—Nov. 3, 2008

    Researchers Find Leishmaniasis Parasites Evade Death by Exploiting the Immune Response to Sand Fly Bites—Aug. 14, 2008

    Scientists Identify New Leads for Treating Parasitic Worm Disease—March 16, 2008

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    Research Feature

    This child from Panama is suffering from Chagas’ disease manifested as an acute infection with swelling of the right eye

    For the first time, researchers have cured mice chronically infected by Trypanosoma cruzi (T. cruzi) parasites. Read about the efforts of NIAID-funded scientists to cure this disease.

    Related Links

    Parasitic Diseases (CDC)

    Control of Neglected Tropical Diseases (WHO)

    See Also

  • Ascariasis
  • Dengue
  • Hookworm
  • Leishmaniasis
  • Leprosy (Hansen’s Disease)
  • Vector Biology
  • Global Research

  •  

    Research Feature

    This child from Panama is suffering from Chagas’ disease manifested as an acute infection with swelling of the right eye

    For the first time, researchers have cured mice chronically infected by Trypanosoma cruzi (T. cruzi) parasites. Read about the efforts of NIAID-funded scientists to cure this disease.

    Related Links

    Parasitic Diseases (CDC)

    Control of Neglected Tropical Diseases (WHO)

    See Also

  • Ascariasis
  • Dengue
  • Hookworm
  • Leishmaniasis
  • Leprosy (Hansen’s Disease)
  • Vector Biology
  • Global Research