National Human Genome Research Institute | National Institutes of Health U.S. Department of Health and Human Services |
Cancer Sequencing Project
Cancer Sequencing Projects (CSPs)The NHGRI-supported, large-scale sequencing centers have begun to tackle the unique challenges associated with using high-throughput DNA sequencing to characterize tumor genomes as described below. In addition to providing important data on genomic aberrations in select tumor types, this research serves to inform methods and systems development as The Cancer Genome Atlas [cancergenome.nih.gov] pilot project, jointly sponsored by NCI and NHGRI, gets underway.
Cancer Genome DataData generated by the two projects will be managed by the investigators and the NHGRI in collaboration with the NCI Center for Bioinformatics (NCICB) [ncicb.nci.nih.gov], using the NCI cancer Biomedical Informatics Grid (caBIG) [cabig.nci.nih.gov] infrastructure. caIntegrator [gforge.nci.nih.gov] provides a framework for integrating and aggregating biomedical research data and provides access to a variety of data types (e.g. microarray-based gene expression, Immunohistochemistry, SNPs, clinical trials data etc.) in a cohesive fashion. Data release policies will be consistent with NHGRI's goals of rapid, complete data release except to the extent that doing so could potentially pose issues of conflict with the privacy of research participants. (See: Large-scale Sequencing Data Release Policy.) Investigators will rapidly release as much enabling data as possible without restrictions or controls, while at the same time adhering to the regulations and practices governing human subjects research and respecting the privacy of the research participants. The specimens being used in both projects have been anonymized, with no link being maintained between the sequence data and the participant identities. To provide further safeguards to protect the privacy of research participants, the data management plan will have two levels of access for the project data: open and controlled access.
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Top of page Requesting Controlled Data AccessThe NHGRI Medical Sequencing Program has created procedures and policies that govern the access of controlled data. Follow the links below for more information or to initiate a request.
Top of page Last Updated: May 8, 2008 |