12-May-2009
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Must Read
F1000 Factor
6.0
New Finding
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Kiyonaka S, Kato K, …, Hamachi I, Mori Y
Proc Natl Acad Sci U S A
2009 Mar 31
106
(13):5400-5 [
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Selected by
| Bernd Nilius
Evaluated 12 May 2009
Recommended
F1000 Factor
3.0
New Finding
Crystal Structure of the ARL2-GTP-BART Complex Reveals a Novel Recognition and Binding Mode of Small GTPase with Effector.
Zhang T, Li S, …, Lai Z, Ding J
Structure
2009 Apr 15
17
(4):602-610 [
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Selected by
| Mitsuhiko Ikura with Christopher Marshall
Evaluated 12 May 2009
Recommended
F1000 Factor
3.0
Hypothesis
Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity.
Van Mooy BA, Fredricks HF, …, Rappé MS, Webb EA
Nature
2009 Mar 5
458
(7234):69-72 [
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Selected by
| Carlos Pedrós-Alió
Evaluated 12 May 2009
Must Read
F1000 Factor
6.0
New Finding
Novel Drug Target
Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells.
Zhou J, Swiderski P, …, Akkina R, Rossi JJ
Nucleic Acids Res
2009 Mar 21 [
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Selected by
| Donald Burke
Evaluated 12 May 2009
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.
Lambert JM, Gorzov P, …, Wiman KG, Bykov VJ
Cancer Cell
2009 May 5
15
(5):376-88 [
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Selected by
| Robert Fecik
Evaluated 12 May 2009
Recommended
F1000 Factor
3.0
New Finding
Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.
van der Veen JN, van Dijk TH, …, Groen AK, Kuipers F
J Biol Chem
2009 May 5 [
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Selected by
| Hannelore Daniel
Evaluated 12 May 2009
Must Read
F1000 Factor
6.0
New Finding
Fat-induced satiety factor oleoylethanolamide enhances memory consolidation.
Campolongo P, Roozendaal B, …, McGaugh JL, Piomelli D
Proc Natl Acad Sci U S A
2009 Apr 27 [
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Selected by
| Hannelore Daniel
Evaluated 12 May 2009
Recommended
F1000 Factor
3.0
New Finding
Mechanisms that specify promoter nucleosome location and identity.
Hartley PD, Madhani HD
Cell
2009 May 1
137
(3):445-58 [
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Selected by
| Rivka Dikstein
Evaluated 12 May 2009
Must Read
F1000 Factor
6.0
Hypothesis
New Finding
Neural progenitors of the postnatal and adult mouse forebrain retain the ability to self-replicate, form neurospheres and undergo multipotent differentiation in vivo.
Neumeister B, Grabosch A, …, Kemler R, Taylor V
Stem Cells
2008 Dec 18
27
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Selected by
| Magdalena Goetz
Evaluated 12 May 2009
Must Read
F1000 Factor
6.0
Hypothesis
New Finding
Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins.
Fallon JL, Baker MR, …, Hamilton SL, Quiocho FA
Proc Natl Acad Sci U S A
2009 Mar 31
106
(13):5135-40 [
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Selected by
| Annette Dolphin
Evaluated 12 May 2009
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