ACR Appropriateness Criteria®
Clinical Condition: Suspected Osteomyelitis in Patients with Diabetes Mellitus
Variant 1: Soft tissue edema without ulcer or neuroarthropathy.
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. Useful for mapping devitalized areas preoperatively. See comments regarding contrast in the text below under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
4 |
If MRI contraindicated |
High |
NUC Tc-99m 3-phase bone scan foot |
1 |
|
Med |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
US foot |
1 |
|
None |
CT foot without contrast |
1 |
|
Min |
FDG-PET foot |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Variant 2: Ulcer with no exposed bone without neuroarthropathy.
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. Useful for mapping devitalized areas preoperatively. See comments regarding contrast in the text below under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
4 |
If MRI contraindicated |
High |
NUC Tc-99m 3-phase bone scan foot |
1 |
|
Med |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
US foot |
1 |
|
None |
CT foot without contrast |
1 |
|
Min |
FDG-PET foot |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Variant 3: Ulcer with exposed bone without neuroarthropathy.
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. Useful for mapping devitalized areas preoperatively. See comments regarding contrast in the text below under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
4 |
If MRI contraindicated |
High |
NUC Tc-99m 3-phase bone scan foot |
1 |
|
Med |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
US foot |
1 |
|
None |
CT foot without contrast |
1 |
|
Min |
FDG-PET foot |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Variant 4: Neuropathy without ulcer
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. See comments regarding contrast in text under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
CT foot without contrast |
5 |
For neuropathy or if MRI contraindicated. |
Min |
NUC Tc-99m 3-phase bone scan foot |
5 |
Useful for pre-radiographic findings of neuropathy. Also if MRI contraindicated. |
Med |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
2 |
|
High |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
US foot |
1 |
|
None |
FDG-PET foot |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Variant 5: Neuroarthropathy with ulcer without exposed bone.
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. See comments regarding contrast in the text below under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
4 |
If MRI contraindicated |
High |
NUC Tc-99m 3-phase bone scan foot |
1 |
|
Med |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
CT foot without contrast |
1 |
|
Min |
US foot |
1 |
|
None |
FDG-PET foot |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Variant 6: Neuroarthropathy with ulcer with exposed bone.
Radiologic Procedure |
Rating |
Comments |
RRL* |
X-ray foot |
9 |
Initial study. Radiographs and MRI are complementary. Both are indicated. |
Min |
MRI foot with contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. See comments regarding contrast in the text below under "Anticipated Exceptions." |
None |
MRI foot without contrast |
9 |
Radiographs and MRI are complementary. Both are indicated. |
None |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan foot |
4 |
If MRI contraindicated |
High |
NUC Tc-99m 3-phase bone scan foot |
1 |
|
Med |
NUC In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
NUC Tc-99m 3-phase bone scan and In-111 WBC scan and Tc-99m sulfur colloid marrow scan foot |
1 |
|
High |
CT foot without contrast |
1 |
|
Min |
US foot |
1 |
|
None |
FDG-PET |
1 |
|
High |
Rating Scale: 1=Least appropriate, 9=Most appropriate |
*Relative Radiation Level |
Note: Abbreviations used in the tables are listed at the end of the "Major Recommendations" field.
Summary of Literature Review
Through the last 50 years there has been much written about the diabetic foot, with little consensus as to whether, when, and what imaging is appropriate. This overview will summarize some of the work and draw conclusions based on the available data. Several clinical situations will be discussed in which osteomyelitis or diabetic pedal disease is suspected, but clinical findings differ because of the presence or absence of edema ulceration and neuropathy.
Please note that although several of the variants have similar recommendations, they do present as unique clinical scenarios.
Soft-Tissue Edema without Ulceration
First, the probability of having osteomyelitis in a diabetic foot without evidence of ulceration is extremely low. Whether there is or is not soft-tissue swelling, these patients have almost no incidence of osteomyelitis and a low incidence of septic arthritis, but some frequency of soft-tissue infections. The only situation in which such a patient can have osteomyelitis is the presence of a "hidden" ulcer that has granulated over and may appear healed. In that situation the risk of osteomyelitis is still extremely low, since the ulcer would not have granulated over if osteomyelitis were present. Therefore, without a clinically apparent ulcer, the role of imaging might be to diagnose neuropathic disease or to see if there is soft-tissue infection only.
Neuropathy without Ulcer
A more difficult question is whether it is the neuroarthropathy or the soft-tissue infection that is causing the soft-tissue swelling. In a patient who has neuroarthropathy, the risk of infection is usually low without ulceration. Radiography can be used as a screening examination. Computed tomography (CT) may pick up neuroarthropathy, which may not be apparent radiographically and may be the cause of the swelling and pain (mimicking infection). CT can rarely exclude the diagnosis of osteomyelitis definitively if there is no edema in the marrow (fat is visible).
Scintigraphy is of indeterminate insensitivity and specificity, whether it is bone scan, indium or indium with sulfur colloid, or even positron emission tomography (PET). Flow images are the best discriminators of infection, but remain imperfect. Magnetic resonance imaging (MRI) likely has the best clinical results in this scenario with or without contrast, but the yield is going to be low in this clinical group of patients, and it is costly.
There is some importance in diagnosing neuropathic disease prior to radiographic changes, as these patients will be treated with altered footwear and orthotics to prevent the progression to deformity. Scintigraphy is, however, extremely sensitive to early neuropathic disease, long before radiographic changes are present. MRI is less sensitive but is a better test if there is a possibility of soft-tissue infection.
Ulcer with Exposed Bone
If an ulcer is present, the risk of infection is quite high, and almost invariable if the ulcer reaches bone. The role of imaging would be to confirm the infection and show extent. Radiography will show the infection, however late. Bone scan is quite nonspecific. Surprisingly, indium scan, even when combined with sulfur colloid marrow imaging, has low specificity, although if the ulcer is away from the joint these techniques are better. MRI has high specificity and sensitivity both with and without contrast. Ultrasound (US) may have promise in long bones but, to date, data about its utility in diagnosing the diabetic foot are quite limited. PET results are similarly poor, as this technique shows metabolic activity primarily and therefore is not specific.
Ulcer with Neuropathy and Exposed Bone
In patients who have diabetes and secondary neuroarthropathy, the infection is usually over an osseous abnormality with an ulcer. If the ulcer tracks down to bone, the risk of osteomyelitis is extremely high, perhaps even higher than in the preceding situation where there is an ulcer without neuropathic deformity. The overall role of imaging therefore, is more to determine the extent of the disease than to definitively diagnose it. Therefore, most authors do not advocate scintigraphy in this situation because of its relative poor spatial resolution for extent of disease; similar conclusions apply to PET.
Similarly, indium-labeled WBC (white blood cell) scanning with or without bone marrow scanning has only mixed sensitivity and specificity for osteomyelitis with neuropathy and yields poor anatomic extent of infection. Radiography has a high specificity but low sensitivity. US is unproven. CT will show the neuroarthropathic disease but not much else. MRI should be performed to determine extent of disease. T1 and fat-suppressed sequences are complementary, and contrast may or may not be used. The use of contrast is more to see the extent of the disease as well as the extent of vascularity, rather than to diagnose infections. Contrast may also help identify necrotic or poorly perfused regions, and to aid in surgical planning.
Summary and Recommendations
If a patient has an ulcer that extends to bone, there is quite likely, but not invariably, osteomyelitis. The best way to confirm this diagnosis and determine the extent of disease is with MRI. If there is no ulcer and there is still a clinical suspicion of infection, MRI is the test of choice. However, conventional radiographs should be done simultaneously in both situations. In indeterminate cases, aspiration and biopsy would be the next step.
If there is soft-tissue swelling the question is, "Is there early neuropathic disease or infection present?" Radiographs should be performed first. If the radiographs are normal, another test should be performed. If the suspicion of infection is low, the next test should probably be a three-phase bone scan. If there is a modest risk of infection, MRI is probably indicated.
Anticipated Exceptions
Nephrogenic systemic fibrosis (NSF, also known as nephrogenic fibrosing dermopathy) was first identified in 1997 and has recently generated substantial concern among radiologists, referring doctors and lay people. Until the last few years, gadolinium-based MR contrast agents were widely believed to be almost universally well tolerated, extremely safe and non-nephrotoxic, even when used in patients with impaired renal function. All available experience suggests that these agents remain generally very safe, but recently some patients with renal failure who have been exposed to gadolinium contrast agents (the percentage is unclear) have developed NSF, a syndrome that can be fatal. Further studies are necessary to determine what the exact relationships are between gadolinium-containing contrast agents, their specific components and stoichiometry, patient renal function and NSF. Current theory links the development of NSF to the administration of relatively high doses (e.g., >0.2mM/kg) and to agents in which the gadolinium is least strongly chelated. The U.S. Food and Drug Administration (FDA) has recently issued a "black box" warning concerning these contrast agents (http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm142882.htm).
This warning recommends that, until further information is available, gadolinium contrast agents should not be administered to patients with either acute or significant chronic kidney disease (estimated glomerular filtration rate [GFR] <30 mL/min/1.73m2), recent liver or kidney transplant or hepatorenal syndrome, unless a risk-benefit assessment suggests that the benefit of administration in the particular patient clearly outweighs the potential risk(s).
Abbreviations
- CT, computed tomography
- FDG-PET, fluorodeoxyglucose-positron emission tomography
- In, indium
- Med, medium
- Min, minimal
- MRI, magnetic resonance imaging
- NUC, nuclear medicine
- Tc, technetium
- US, ultrasound
- WBC, white blood cell
Relative Radiation Level |
Effective Dose Estimated Range |
None |
0 |
Minimal |
<0.1 mSv |
Low |
0.1-1 mSv |
Medium |
1-10 mSv |
High |
10-100 mSv |