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Pu Paul Liu, M.D., Ph.D.
Acting Chief & Senior Investigator, Genetics and Molecular Biology Branch
Head, Oncogenesis and Development Section
Selected Publications
Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M,
Marin-Padilla M, Collins FS, Wynshaw-Boris A, and Liu PP. Failure of
embryonic hematopoiesis and lethal hemorrhages in mouse embryos
heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell, 87:687-696. 1996. [PubMed]
Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, Owens J, Eckhaus M, Bodine D, Liu PP. Chromosome 16 inversion-generated fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia. Nat Genet, 23:144-146. 1999. [PubMed]
Blake T, Adya N, Oates A, Zon L, Chitnis A, Weinstein BM, Liu PP. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood, 96:4178. 2000. [PubMed]
Lyons SE, Xu B, Oates A, Zon L, Thisse B, and Liu PP. A unique myeloid-specific c/ebp transcription factor is present in zebrafish. Blood, 97:2611-2617. 2001. [PubMed]
Kundu M, Javed A, Jeon J-P, Horner A, Shum L, Eckhaus M, Muenke M, Lian J, Yang Y, Nuckolls GH, Stein G, and Liu PP. Cbfβ interacts with Runx2 and has a critical role in bone development. Nature Genetics, 32: 639-644, 2002. [PubMed]
Lyons S, Lawson N, Lei L, Bennett P, Weinstein B, and Liu PP. A nonsense mutation in zebrafish gata-1 causes the bloodless phenotype in Vlad Tepes. Proc Natl Acad Sci USA 99:5454-5459, 2002. [PubMed]
Nishikawa K, Kobayashi M, Masumi A, Lyons LE, Weinstein BM, Liu PP and Yamamoto M. Self-association of GATA-1 enhances the transcriptional activity in zebrafish embryo. Mol Cell Biol, 23:8295-8305. 2003. [PubMed]
Castilla LH, Perrat P, Martinez NJ, Landrette S, Keys R, Oikemus S, Flanegan J, Garrett L, Dutra A, Pihan GA, Wolff L, Liu PP. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci USA, 101:4924-4929. 2004. [PubMed]
Kundu M, Compton S, Garrett-Beal L, Stacy T, Starost MF, Eckhaus M, Speck NA, Liu PP. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma.
Blood, 106(10):3621-4. 2005. [PubMed]
Sood R., English, M.A., Jones, M., Mullikin, J., Wang, D.M., Anderson M., Wu, D., Chandrasekharappa, S.C., Yu, J., Zhang, J., and Liu, P.P. Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods, 39(3):220-227. 2006. [PubMed]
Khan, A., Hyde, R.K., Dutra, A., Mohide, P., Liu, P. CBFB (core binding factor beta) haploinsufficiency due to an interstitial deletion at 16q21q22 resulting in delayed cranial ossification, cleft palate, congenital heart anomalies, and feeding difficulties but favourable outcome. Am J Med Genet A, 140(21):2349-54. 2006. [PubMed]
Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood, 109:3432-40. 2007. [PubMed]
Last Reviewed: June 22, 2009
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