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Yardena Samuels, Ph.D.
Investigator, Cancer Genetics Branch
Head, Molecular Cancer Genetics Section
Selected Publications
Samuels-Lev Y, O'Connor DJ, Bergamaschi D., Trigiante G, Hsieh JK, Zhong S, Campargue I., Naumovski L., Crook T., and Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Molecular Cell, 8:781-94. 2001. [PubMed]
Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, and Lu X. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet, 33:162-167. 2003. [PubMed]
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science, 304:554. 2004. [PubMed]
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol, 24(3):1341-1350. 2004. [PubMed]
Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle, 3:1221-1224. 2004. [PubMed]
Samuels Y, Diaz LA, Jr., Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell, 7:561-573. 2005. [PubMed]
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature, 436:792. 2005. [PubMed]
Bergamaschi D, Samuels Y, Zhong S, Lu X. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. Oncogene, 24(23):3836-41. 2005. [PubMed]
Samuels Y, Zhu J, Lengauer C. Inhibiting Phosphoinositide 3-Kinases. Cancer Biol Ther, 4(5). 2005. [PubMed]
Samuels Y, Ericson K. Oncogenic PI3K and its role in cancer. Current Opinion in Oncology Curr Opin Oncol, 18(1):77-82. 2006. [PubMed]
Samuels Y, Diaz LA, Jr., Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, and Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell, 7(6): 561-573. 2006. [PubMed]
Bergamaschi D, Samuels Y, Sullivan A, Gasco M, Syed N, Zvelebil M, Breyssens H, Bisso A, Smith P, Del Sal G, Crook T, Lu X. iASPP preferentially binds the proline rich region of p53 and modulates the apoptotic function of codon 72 polymorphic p53. Nature Genetics, 38(10):1133-1141. 2006. [PubMed]
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, and Amzel LM. The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations. Science, 318:1744-1748. 2007. [PubMed]
Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res, 68:10300-10306. 2008. [PubMed]
Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet, 41:518-520. 2009. [PubMed]
Last Updated: June 1, 2009
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