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Opioid Peptides: Molecular Pharmacology, Biosynthesis, and Analysis |
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NIDA Research Monograph, Number 70 [Printed in 1986]This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph.Download Monograph70.pdf - Opioid Peptides: Molecular Pharmacology, Biosynthesis, and Analysis (4.6 MB) Foreword-----v Introduction-----1 Folding and Enzymatic Processing of Precursors of Biologically Active Peptides and Proteins-----3 Biosynthesis of Opioid Peptides-----21 Proenkephalin Biosynthesis in the Rat-----43 Enzymes in the Metabolism of Opioid Peptides: Isolation, Assay, and Specificity-----66 Isolation and Identification of Opioid Peptides-----92 B-Endorphin: Naturally Occurring or Synthetic Agonists and Antagonists-----109 Enkephalin Degrading Enzyme Inhibitors: A Physiological Way to New Analgesics and Psychoactive Agents-----128 Progress in the Characterization of the Opioid Receptor Subtypes: Peptides as Probes. Future Directions-----155 Regulation of Agonist Binding to Opioid Receptor Types by Sodium and GTP: Relevance to Receptor Function-----175 Opioid Receptors for the Dynorphin Peptides-----192 Computer Analysis of Radioligand Data: Advantages, Problems, and Pitfalls-----209 Recent Developments in Bioassay Using Selective Ligands and Selective In Vitro Preparations-----223 Endorphins and Memory Regulation-----237 Current Status of RIA Methods for the Analysis of Enkephalins and Endorphins-----255 The Analysis of Endogenous Opioid Peptides With HPLC, Radioreceptor Assay, Radioimunoassay, and Mass Spectrometry-----304 Reverse Phase HPLC of Peptides: Application to the Opioid Peptides-----319 Peptides as Drugs in the Treatment of Opiate Addiction-----337 Progress in the Potential Use of Enkephalin Analogs-----367 Opioid Peptides as Drug Products: FDA Regulatory Requirements-----385 A Few Thoughts on the Development and Regulation of Neuropeptides-----405 |
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