NIDA Research Monograph, Number 54 [Printed in 1984]
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Table of Contents
Preface-----ix
In Memoriam: H. 0. J. Collier-----1
Sydney Archer
Mechanisms of Tolerance and Dependence: An Overview-----4
Leo G. Abood
Phenomenology and Theoretical Basis of Tolerance and Dependence-----12
William R. Martin
Contributions of Neuropharmacology to Understanding Mechanisms of Tolerance and Dependence-----27
Martin W. Adler and Ellen B. Geller
Various Factors Which Affect the Rate of Development of Tolerance and Physical Dependence to Abused Drugs-----39
William L. Dewey
Genetic Determinants of Responses to Drugs of Abuse: An Evaluation of Research Strategies-----50
Louis Shuster
Opioid Tolerance and Dependence in Light of the Multiplicity of Opioid Receptors-----70
Rudiger Schulz and Albert Herz
Sites and Mechanisms of Dependence in the Myenteric Plexus of Guinea Pig Ileum-----81
H. 0. J. Collier and J. F. Tucker
Biochemical Reactions Between Opiate Receptor Binding and Inhibition of Neurotransmission-----95
Doris H. Clouet and Norifumi Yonehara
The Role of Adenyl Cyclase in Opiate Tolerance and Dependence-----109
Werner A. Klee, Graeme Milligan, William S. Simonds, and Bruno Tocque
Mechanisms of Multiple Cellular Adaptation Processes in Clonal Cell Lines During Chronic Opiate Treatment-----119
Ping-Yee Law, Michael T. Griffin, and Horace H. Loh
The Opioid-Induced Desensitization (Tolerance) in Neuroblastoma X Glioma NG 108-15 Hybrid Cells: Results from Receptor Uncoupling-----136
Michael Wuster and Tomnaso Costa
Opiate Receptor Upregulation and Functional Supersensitivity-----146
R. Suzanne Zukin, Ann Tempel, and Eliot L. Gardner
The Role of Dynorphin in Narcotic Tolerance Mechanisms-----162
Nancy M. Lee
Post-Translational Processing of Neuropeptide Precursors-----168
Richard E. Mains and Betty A. Eipper
Opiate-Mediated Control of Luteinizing Hormone in the Male; Role in the Development of Narcotic Tolerance and Physical Dependence-----184
Theodore J. Cicero
Modulation of Opioid Physical Dependence During the Hibernation Cycle-----209
Alexander L. Beckman, Carmen Llados-Eckman, Steven K. Salzman, and Toni L. Stanton
Neurophysiological Investigations of Opiate Tolerance and Dependence in the Central Nervous System-----239
Steven Jon Henriksen
Spinal Cord Tissue Culture Models for Analyses of Opioid Analgesia, Tolerance and Plasticity-----260
Stanley M. Crain
Experimental Approaches Toward Determining the Neuronal Circuits Most Affected by Chronic Opiate Administration-----293
Robert Elde
Effects of Opiates and Neuropeptides on Immune Functions-----300
Robert E. Faith, N. P. Plotnikoff, and A. J. Murgo
Changes in CNS Sensitivity to Cannabinoids with Repeated Treatment: Tolerance and Auxoesthesia-----312
R. Karler, L. D. Calder, and S. A. Turkanis
Catecholamine-Independent Behavioral and Neurochemical Effects of Cocaine in Rats-----323
Karen Gale
Barbiturate Tolerance and Physical Dependence: Contribution of Pharmacological Factors-----333
Michiko Okamoto
Behavioral and Biochemical Studies in Rats After Chronic Exposure to Nicotine-----348
Leo G. Abood, Susan Grassi, Maria Costanzo, and Jeffrey Junig
Psychobiological Foundations of Behaviors Induced by Amphetamines-----356
Philip M. Groves and David S. Segal
Index-----367
List of NIDA Research Monographs-----371
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