HIV/AIDS

Clinical Trials

Clinical Research Sites Conducting NIAID-Supported HIV Vaccine Trials, 2009

View a full-size version of the map. (Credit: NIAID)

HIV/AIDS Vaccine Clinical Trial Partnerships

NIAID supports a number of HIV vaccine trials around the world through several internal and external organizations.

Government Links

• The NIAID Division of AIDS (DAIDS)—Launched in 1986, DAIDS sponsors and oversees a wide range of trial related activities.
• The NIAID Dale and Betty Bumpers Vaccine Research Center—The Vaccine Research Center (VRC) at the National Institutes of Health was established in 1999 to facilitate research in vaccine development. 

Non-Government Links

• HIV Vaccine Trials Network—Formed in 1999 by NIAID, the HIV Vaccine Trials Network (HVTN) is an international collaboration of scientists and educators that performs clinical research through a network of domestic and international clinical trials sites.
• Conducts all phases of clinical trials: evaluating experimental vaccines for safety and the ability to stimulate immune responses; testing vaccine efficacy; developing and validating assays
• Develops, implements, analyzes, and prioritizes vaccine design concepts and protocols through scientific committees
• Partnership for AIDS Vaccine Evaluation (PAVE)—PAVE is a voluntary consortium of U.S. government agencies and U.S. government-funded organizations involved in HIV vaccine research. Members of PAVE include DAIDS, the Office of AIDS Research, the HVTN, the Dale and Betty Bumpers VRC, the U.S. Agency for International Development, the U.S. Military HIV Research Program, the Centers of Disease Control and Prevention, and the International AIDS Vaccine Initiative.
• U.S. Military HIV Research Program (USMHRP)—Established in 1985 to protect troops entering endemic HIV areas, this program brings together scientists from the U.S. Army, Navy, and Air Force. DAIDS jointly plans and executes HIV/AIDS research projects with the USMHRP through an interagency agreement.
• Center for HIV/AIDS Vaccine Immunology (CHAVI)—CHAVI was established by DAIDS as part of the Global HIV/AIDS Vaccine Enterprise. It aims to elucidate basic sciences questions and conduct early phase clinical trials of HIV vaccine candidates at clinical sites around the world. Dr. Barton Haynes of Duke University serves as the principle investigator of CHAVI’s scientific leadership group.
• Global HIV Vaccine Enterprise (GHAVE)—GHAVE is a virtual consortium of organizations committed to the development of a preventive HIV/AIDS vaccine. It's goal is to implement shared scientific plans, mobilize resources, and improve worldwide collaborations.
• International AIDS Vaccine Initiative (IAVI)—IAVI was founded in 1996 to speed discovery of an HIV vaccine. It partners worldwide with private companies, academic institutions, and government agencies, such as NIH.

List of Ongoing HIV Vaccine Trials

Government Links

• AIDSinfo—This government Web site has information on HIV/AIDS treatment and prevention guidelines, information on drugs and vaccines, a database of all federally funded and privately sponsored HIV/AIDS clinical trials, and HIV/AIDS-related health topics.
• Dale and Betty Bumpers Vaccine Research Center (VRC)—List of VRC vaccine trials.

Non-Government Links

• HIV Vaccine Trials Network (HVTN)—Has information on the current HVTN vaccine trials.
• International AIDS Vaccine Initiative (IAVI)—A database of worldwide HIV vaccine trials.

Other Resources

Fact sheet: Clinical Research on HIV Vaccines

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