Is There Intravascular Hemolysis in Patients With Pulmonary Hypertension?

This study is currently recruiting participants.

Verified by Rabin Medical Center, October 2007

First Received: July 15, 2007 Last Updated: October 14, 2007 History of Changes

Sponsored by:	Rabin Medical Center
Information provided by:	Rabin Medical Center
ClinicalTrials.gov Identifier:	NCT00502398

Purpose

Patients with hemolytic disorders (e.g. sickle cell anemia or thalassemia) are known to develop pulmonary hypertension. Hemolysis is where red blood cells are destroyed and their contents released into the circulation.

It is thought that these red-cell contents cause constriction and thrombosis of the blood vessels in the lungs.

Conversely, it is possible that patients with pulmonary hypertension have hemolysis.

In this study we will be drawing blood from a range of patients and normal controls for a panel of blood tests related to hemolysis.

Condition	Intervention
Pulmonary Artery Hypertension	Procedure: Blood test

Study Type:	Observational
Study Design:	Prospective

Resource links provided by NLM:

MedlinePlus related topics: High Blood Pressure Pulmonary Hypertension

U.S. FDA Resources

Further study details as provided by Rabin Medical Center:

Study Start Date:

September 2007

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

One of the following four conditions :

Pulmonary artery hypertension
Obstructive sleep apnea with pulmonary hypertension
Lung transplant candidates without pulmonary hypertension
Normal Controls

Exclusion Criteria:

Known hemolytic disorder
Recent blood loss (<3 months)
Recent blood transfusion (<3 months)
Liver disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00502398

Contacts

Contact: Ben Fox, MRCP

+972 3 937 7221

foxb@clalit.org.il

Locations

Israel
Pulmonary Institute, Rabin Medical Center (Beilinson campus)	Recruiting
Petach Tikva, Israel, 49100
Contact: Ben Fox, MRCP foxb@clalit.org.il

Sponsors and Collaborators

Rabin Medical Center

Investigators

Principal Investigator:

Mordechai Kramer, MD

Rabin Medical Center

More Information

No publications provided

Study ID Numbers:	RMC074490CTIL
Study First Received:	July 15, 2007
Last Updated:	October 14, 2007
ClinicalTrials.gov Identifier:	NCT00502398 History of Changes
Health Authority:	Israel: Clalit Health Services

Study placed in the following topic categories:

Respiratory Tract Diseases
Hypertension, Pulmonary
Lung Diseases

Vascular Diseases
Hemolysis
Hypertension

Additional relevant MeSH terms:

Respiratory Tract Diseases
Hypertension, Pulmonary
Lung Diseases

Vascular Diseases
Cardiovascular Diseases
Hypertension

ClinicalTrials.gov processed this record on September 11, 2009