Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves’ Disease

This study has been completed.

First Received: July 18, 2007 Last Updated: July 19, 2007 History of Changes

Sponsors and Collaborators:	University of Campinas, Brazil Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by:	University of Campinas, Brazil
ClinicalTrials.gov Identifier:	NCT00505011

Purpose

Cigarette smoking is a well-recognized risk factor of Graves’ disease and, particularly, Graves’ ophthalmopathy.

Hence, germline polymorphisms of detoxification genes and genes belonging to the major DNA repair/apoptosis pathways might have an important role in disease susceptibility. In addition, as some of these genes are regulated by thyroid hormones, they could affect the outcome of these patients. Our objective was to assess the influence of the GST, CYP and TP53 gene polymorphisms in the risk of Graves' disease and its outcome.

Condition
Graves' Disease

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Case Control, Retrospective/Prospective Study
Official Title:	Study of the Influence of the GST, CYP and TP53 Gene Polymorphisms in the Risk of Graves' Disease and Its Outcome.

Resource links provided by NLM:

MedlinePlus related topics: Smoking Smoking and Youth

U.S. FDA Resources

Further study details as provided by University of Campinas, Brazil:

Enrollment:	1998
Study Start Date:	February 1998
Study Completion Date:	February 2007

Detailed Description:

Although the role of many polymorphisms of genes related to toxins’ metabolism has been extensively investigated regarding the susceptibility to thyroid cancer, their influence in thyroid autoimmune diseases risk is still largely unknown. Hence, this study was designed to assess the influence of GSTT1, GSTM1, GSTP1, CYP1A1 and 72TP53 polymorphic inheritance on the susceptibility to Graves' disease and to its response to the treatment.

Eligibility

Ages Eligible for Study:	2 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Graves' disease patients

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00505011

Sponsors and Collaborators

University of Campinas, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo

Investigators

Principal Investigator:

Laura S Ward, MD, PhD

State University of Campinas- UNICAMP

More Information

No publications provided

Study ID Numbers:	17072007
Study First Received:	July 18, 2007
Last Updated:	July 19, 2007
ClinicalTrials.gov Identifier:	NCT00505011 History of Changes
Health Authority:	Brazil: National Committee of Ethics in Research

Keywords provided by University of Campinas, Brazil:

susceptibility
genes
environment
ophthalmopathy
outcome

Study placed in the following topic categories:

Goiter
Autoimmune Diseases
Disease Susceptibility
Eye Diseases
Graves Disease
Endocrine System Diseases
Exophthalmos

Smoking
Graves' Disease
Endocrinopathy
Genetic Predisposition to Disease
Orbital Diseases
Thyroid Diseases
Hyperthyroidism

Additional relevant MeSH terms:

Goiter
Autoimmune Diseases
Immune System Diseases
Eye Diseases
Graves Disease

Endocrine System Diseases
Orbital Diseases
Hyperthyroidism
Thyroid Diseases
Exophthalmos

ClinicalTrials.gov processed this record on September 11, 2009