Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx - Full Text View

Sponsors and Collaborators:	Vanderbilt-Ingram Cancer Center National Cancer Institute (NCI)
Information provided by:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00899340

Purpose

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.

PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Condition	Intervention
Head and Neck Cancer	Genetic: gene expression analysis Genetic: microarray analysis Genetic: protein expression analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Study Type:	Observational
Official Title:	Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Resource links provided by NLM:

MedlinePlus related topics: Cancer Head and Neck Cancer

U.S. FDA Resources

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:

Development of biomarkers for early detection or recurrence surveillance [ Designated as safety issue: No ]
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx [ Designated as safety issue: No ]

Estimated Enrollment:	50
Study Start Date:	May 2006
Primary Completion Date:	May 2009 (Final data collection date for primary outcome measure)

Detailed Description:

OBJECTIVES:

To investigate if some of the differences in gene expression are also reflected at the protein level.
To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

DISEASE CHARACTERISTICS:

Diagnosis of squamous cell carcinoma of the oropharynx
Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00899340

Sponsors and Collaborators

Vanderbilt-Ingram Cancer Center

National Cancer Institute (NCI)

Investigators

Study Chair:

Wendell G. Yarbrough, MD, FACS

Vanderbilt-Ingram Cancer Center

More Information

Additional Information:

Clinical trial summary from the National Cancer Institute's PDQ® database This link exits the ClinicalTrials.gov site

No publications provided

Study ID Numbers:	CDR0000558939, VU-VICC-HN-0624, VU-VICC-IRB-060380
Study First Received:	May 9, 2009
Last Updated:	June 3, 2009
ClinicalTrials.gov Identifier:	NCT00899340 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Cancer Institute (NCI):

recurrent squamous cell carcinoma of the oropharynx
stage I squamous cell carcinoma of the oropharynx
stage II squamous cell carcinoma of the oropharynx
stage III squamous cell carcinoma of the oropharynx
stage IV squamous cell carcinoma of the oropharynx

Study placed in the following topic categories:

Otorhinolaryngologic Neoplasms
Otorhinolaryngologic Diseases
Oropharyngeal Cancer, Adult
Pharyngeal Neoplasms
Squamous Cell Carcinoma
Pharyngeal Diseases
Recurrence
Carcinoma

Head and Neck Neoplasms
Epidermoid Carcinoma
Neoplasms, Squamous Cell
Stomatognathic Diseases
Carcinoma, Squamous Cell
Oropharyngeal Neoplasms
Neoplasms, Glandular and Epithelial

Additional relevant MeSH terms:

Otorhinolaryngologic Diseases
Neoplasms by Histologic Type
Otorhinolaryngologic Neoplasms
Pharyngeal Neoplasms
Pharyngeal Diseases
Carcinoma
Neoplasms

Neoplasms by Site
Head and Neck Neoplasms
Neoplasms, Squamous Cell
Stomatognathic Diseases
Carcinoma, Squamous Cell
Oropharyngeal Neoplasms
Neoplasms, Glandular and Epithelial

ClinicalTrials.gov processed this record on September 11, 2009