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Sponsors and Collaborators: |
University of Arizona National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00898703 |
RATIONALE: Studying samples of blood in the laboratory from patients with current or previous cancer may help doctors learn more about biomarkers related to cancer.
PURPOSE: This research study is looking at blood samples in women with breast cancer or a history of breast cancer.
Condition | Intervention |
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Breast Cancer |
Other: flow cytometry Other: immunoenzyme technique Other: laboratory biomarker analysis |
Study Type: | Observational |
Official Title: | QUANTIFICATION OF CIRCULATING ENDOTHELIAL CELLS (CEC) AND PLASMA ANGIOGENIC FACTORS IN PATIENTS WITH BREAST CANCER |
Estimated Enrollment: | 200 |
Study Start Date: | August 2001 |
Estimated Primary Completion Date: | August 2009 (Final data collection date for primary outcome measure) |
OBJECTIVES:
Primary
Secondary
OUTLINE: Peripheral blood and plasma samples are collected for analysis of circulating endothelial cells (CEC) and angiogenic growth factor levels. Blood samples from patients initiating a new chemotherapy or hormonal therapy for breast cancer are collected at baseline and at 3 and 6 weeks following the start of treatment. CEC are quantified via flow cytometry and plasma angiogenic markers are assessed via ELISA.
PROJECTED ACCRUAL: A total of 100 patients with active, measurable breast cancer and 100 patients with a prior history of breast cancer will be accrued for this study.
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
United States, Arizona | |
Arizona Cancer Center at University of Arizona Health Sciences Center | Recruiting |
Tucson, Arizona, United States, 85724 | |
Contact: Alison T. Stopeck, MD 866-278-1554 astopeck@azcc.arizona.edu |
Principal Investigator: | Alison T. Stopeck, MD | University of Arizona |
Study ID Numbers: | CDR0000597587, UARIZ-HSCA01134 |
Study First Received: | May 9, 2009 |
Last Updated: | May 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00898703 History of Changes |
Health Authority: | Unspecified |
breast cancer |
Skin Diseases Breast Neoplasms Angiogenesis Inducing Agents Breast Diseases |
Neoplasms Neoplasms by Site Skin Diseases Breast Neoplasms Breast Diseases |