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| Sponsored by: |
National Cancer Institute (NCI) |
|---|---|
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00898001 |
Purpose
RATIONALE: Studying samples of tumor tissue or blood from patients with cancer in the laboratory may help doctors learn more about cancer and the development of multidrug resistance in patients.
PURPOSE: This laboratory study is looking at multidrug resistance proteins in patients enrolled in clinical trials outside of the National Cancer Institute Center for Cancer Research.
| Condition | Intervention |
|---|---|
|
Brain and Central Nervous System Tumors Breast Cancer Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific |
Genetic: gene expression analysis Genetic: protein expression analysis Genetic: reverse transcriptase-polymerase chain reaction Other: flow cytometry Other: immunohistochemistry staining method |
| Study Type: | Observational |
| Official Title: | Multidrug Resistance Molecular Target Analysis of Human Samples Collected in Clinical Trials Performed Outside of the Intramural National Cancer Institute |
| Estimated Enrollment: | 9999 |
| Study Start Date: | December 2005 |
OBJECTIVES:
OUTLINE: Tumor tissue or blood samples that have been previously collected from patients are analyzed for P-glycoprotein and other multidrug transporters (e.g., MRP-1 and ABCG2) by immunohistochemistry, microarray analysis, and reverse transcriptase-polymerase chain reaction.
The identity of individual patients remains confidential. No results of sample analyses are provided to patients or family members.
PROJECTED ACCRUAL: An unlimited number of patient samples will be accrued for this study.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Contacts and Locations| United States, Arizona | |
| Arizona Clinical Research Center, Incorporated | Recruiting |
| Tucson, Arizona, United States, 85715 | |
| Contact: Manuel R. Modiano, MD 520-290-2510 | |
| United States, Maryland | |
| Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office | Recruiting |
| Bethesda, Maryland, United States, 20892-1182 | |
| Contact: Clinical Trials Office - Warren Grant Magnusen Clinical Center 888-NCI-1937 | |
| United States, Pennsylvania | |
| Children's Hospital of Pittsburgh | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| Contact: Clinical Trials Office - Children's Hospital of Pittsburgh 412-692-5573 | |
| United States, South Carolina | |
| Cancer Centers of the Carolinas - Grove Commons | Recruiting |
| Greenville, South Carolina, United States, 29605 | |
| Contact: Jay D. Walls, MD 864-241-6251 jay.walls@usoncology.com | |
| Denmark | |
| Copenhagen County Herlev University Hospital | Recruiting |
| Copenhagen, Denmark, DK-2730 | |
| Contact: Inge M. Svane, PhD 45-44-884-488 inge.m.svane@dadlnet.dk | |
| University of Copenhagen | Recruiting |
| Copenhagen, Denmark, 2100 | |
| Contact: John Zibert 45-35-32-61-75 zibert@musling.dk | |
| Peru | |
| Instituto Nacional de Enfermedades Neoplasicas | Recruiting |
| Lima, Peru, 34 | |
| Contact: Contact Person 51-1-612-9700 | |
| Principal Investigator: | Susan E. Bates, MD | National Cancer Institute (NCI) |
More Information
| Study ID Numbers: | CDR0000352421, NCI-04-C-N067 |
| Study First Received: | May 9, 2009 |
| Last Updated: | May 9, 2009 |
| ClinicalTrials.gov Identifier: | NCT00898001 History of Changes |
| Health Authority: | Unspecified |
|
recurrent childhood ependymoma recurrent childhood visual pathway and hypothalamic glioma recurrent childhood visual pathway glioma recurrent childhood brain tumor childhood high-grade cerebral astrocytoma childhood low-grade cerebral astrocytoma recurrent childhood cerebral astrocytoma childhood infratentorial ependymoma childhood oligodendroglioma childhood supratentorial ependymoma |
recurrent childhood cerebellar astrocytoma recurrent breast cancer stage I breast cancer stage II breast cancer stage IIIA breast cancer stage IIIB breast cancer stage IIIC breast cancer stage IV breast cancer unspecified adult solid tumor, protocol specific unspecified childhood solid tumor, protocol specific |
|
Brain Neoplasms Skin Diseases Astrocytoma Brain Tumor, Childhood Breast Neoplasms Oligodendroglioma |
Glioma Central Nervous System Neoplasms Breast Diseases Recurrence Ependymoma Nervous System Neoplasms |
|
Neoplasms Neoplasms by Site Skin Diseases Nervous System Diseases |
Breast Neoplasms Central Nervous System Neoplasms Breast Diseases Nervous System Neoplasms |
