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| Sponsored by: |
Massachusetts General Hospital |
|---|---|
| Information provided by: | Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT00938028 |
Purpose
The purpose of this study is to evaluate the effects of storage and handling on fecal samples collected for metabolomic, proteomic and microbiomic and analysis.
| Condition |
|---|
|
Infant |
| Study Type: | Observational |
| Study Design: | Prospective |
| Official Title: | Fecal Samples for Metabolomic and Microbiomic Studies: Effects of Preparation and Storage |
Stool samples
| Enrollment: | 4 |
| Study Start Date: | April 2009 |
| Study Completion Date: | May 2009 |
| Primary Completion Date: | May 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Microbiome, Metabolome, Stool, Toddler
healthy infant stool samples
|
Background
Human fecal collection for clinical or research studies usually occurs at the residence of the subject, an environment not equipped with measures to accommodate proper preparation and storage of samples for microbiome and metabolome analysis.
Aims
To evaluate the effects of storage and handling on fecal samples collected for metabolomic, proteomic and microbiomic and analysis.
Methods
Fecal samples will be collected within several minutes of voiding from healthy infants at the time of diaper change at day-care center.
Samples will be divided into 7 tubes, and subjected to different storage temperatures, before preforming microbial analysis by DNA sequencing, and metabolome analysis by H1NMR spectroscoty.
Eligibility| Ages Eligible for Study: | 12 Months to 20 Months |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Healthy toddlers in a day care center
Inclusion Criteria:
Contacts and Locations| United States, Massachusetts | |
| MassGeneral for Children | |
| Boston, Massachusetts, United States, 02114 | |
| Principal Investigator: | Harland Winter, MD | MGH |
More Information
| Responsible Party: | MassGeneral Hospital for Children ( Harland Winter, MD ) |
| Study ID Numbers: | 2009p-000636 |
| Study First Received: | July 9, 2009 |
| Last Updated: | July 17, 2009 |
| ClinicalTrials.gov Identifier: | NCT00938028 History of Changes |
| Health Authority: | United States: Institutional Review Board |
|
microbiome metabolome stool |
fecal samples handling toddler |
