- Samuel F. B. Morse Papers at the Library of Congress, 1793-1919
- Selected Civil War Photographs
- September 11, 2001, Documentary Project
- Slaves and the Courts, 1740-1860
- Small-Town America: Stereoscopic Views from the Robert Dennis Collection, 1850-1920
- The South Texas Border, 1900-1920: Photographs from the Robert Runyon Collection
- Southern Mosaic: The John and Ruby Lomax 1939 Southern States Recording Trip
- Spalding Base Ball Guides, 1889-1939
- The Spanish-American War in Motion Pictures
- The Stars and Stripes: The American Soldiers' Newspaper of World War I, 1918-1919
- "Suffering Under a Great Injustice": Ansel Adams's Photographs of Japanese-American Internment at Manzanar
- Sunday School Books: Shaping the Values of Youth in Nineteenth-Century America