Full Text View
Tabular View
No Study Results Posted
Related Studies
Quality Improvement in Stroke Prevention (QUISP)
This study has been completed.
First Received: May 18, 2006   Last Updated: April 25, 2007   History of Changes
Sponsors and Collaborators: University of California, San Francisco
Kaiser Permanente
Information provided by: University of California, San Francisco
ClinicalTrials.gov Identifier: NCT00328640
  Purpose

Is a secondary prevention intervention, focused on implementation of standardized pre-printed discharge orders for hospitalists, effective at increasing utilization of the following evidence-based treatments 6 months after discharge for ischemic stroke:

  1. Treatment with statins,
  2. Control of hypertension, and
  3. Anticoagulation in patients with atrial fibrillation.

Condition Intervention Phase
Ischemic Stroke
Drug: Optimal treatment
Phase IV

Study Type: Interventional
Study Design: Prevention, Randomized, Single Blind, Placebo Control, Single Group Assignment, Safety Study
Official Title: Secondary Prevention After Ischemic Stroke: A Trial of an Evidence-Based System-Wide Intervention

Further study details as provided by University of California, San Francisco:

Primary Outcome Measures:
  • Medication utilization
  • Best Practices
  • Recurrent stroke

Secondary Outcome Measures:
  • Mortality
  • Morbidity
  • Cost
  • Hospital readmission

Estimated Enrollment: 1500
Study Start Date: December 2005
Study Completion Date: March 2007
Detailed Description:

There are several proven strategies for prevention of recurrent ischemic stroke, including use of statins, treatment of hypertension, and anticoagulation in patients with atrial fibrillation. Preliminary analyses suggest that only 9-15% of Kaiser Permanente Northern California’s ischemic stroke patients receive optimal care for secondary prevention of stroke. The purpose of this study is to determine whether or not a quality improvement (QI) intervention can improve the care received by stroke patients. This project consists of a randomized trial of standardized stroke discharge order forms to improve adherence with best practices in secondary stroke prevention. The primary research question is: Is a secondary prevention intervention, focused on implementation of standardized pre-printed discharge orders for hospitalists, effective at increasing utilization of the following evidence-based treatments 6 months after discharge for ischemic stroke: (1) treatment with statins, (2) control of hypertension, and (3) anticoagulation in patients with atrial fibrillation. The primary outcome will be the proportion of patients receiving optimal treatment, as defined by these three goals. The impact of the intervention will be measures as a change after-to-before at intervention hospitals compared to non-intervention (control) hospitals, with the institution as the unit of analysis.

Secondary analyses will evaluate the impact of the intervention on each of these components and on 6-month and

1-year rates of mortality, readmission for stroke, and costs of care after discharge.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Ischemic stroke Kaiser-Permanente Health Plan Member with Pharmacy Benefit Discharged alive to home

Exclusion Criteria:

tpA patients Hemorrhagic stroke TIA Significant comorbidities

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00328640

Locations
United States, California
Kaiser-Permanente Division of Research
Oakland, California, United States, 94612
Sponsors and Collaborators
University of California, San Francisco
Kaiser Permanente
Investigators
Study Director: David M Grosvenor, MPH University of California, San Francisco
Principal Investigator: S C Johnston, MD University of California, San Francisco
  More Information

No publications provided

Study ID Numbers: MM 0620 0404
Study First Received: May 18, 2006
Last Updated: April 25, 2007
ClinicalTrials.gov Identifier: NCT00328640     History of Changes
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, San Francisco:
CVA
Ischemic stroke

Study placed in the following topic categories:
Cerebral Infarction
Stroke
Vascular Diseases
Neoplasm Metastasis
Brain Ischemia
Central Nervous System Diseases
Brain Infarction
Ischemia
Brain Diseases
Infarction
Cerebrovascular Disorders

Additional relevant MeSH terms:
Pathologic Processes
Cerebral Infarction
Nervous System Diseases
Stroke
Vascular Diseases
Brain Ischemia
Central Nervous System Diseases
Cardiovascular Diseases
Brain Infarction
Ischemia
Brain Diseases
Cerebrovascular Disorders

ClinicalTrials.gov processed this record on September 11, 2009