Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
Royal Brompton & Harefield NHS Foundation Trust |
---|---|
Information provided by: | Royal Brompton & Harefield NHS Foundation Trust |
ClinicalTrials.gov Identifier: | NCT00854958 |
Oral allergy syndrome is a type of food allergy which mainly affects people with springtime hay fever. It is caused by a cross-reaction, between antibodies to pollens, usually birch tree pollen, and allergens in many different plant foods. It is characterised by symptoms of itching and/or swelling in the mouth and/or throat when eating certain fruits vegetables and nuts. Many of the allergens causing OAS are destroyed by heat, making allergy testing using traditional allergen extracts unreliable. Prick testing or challenging with fresh foods is more reliable, but time consuming, inconvenient and largely unavailable. Pilot study results suggest the characteristic symptoms and foods involved in OAS allow accurate diagnosis using clinical history alone, which forms the basis for the hypothesis of this proposal that OAS can be diagnosed accurately by use of a validated questionnaire alone. The diagnostic questionnaire (PFSDQ), revised from the results of the pilot study, will be tested against two reference test methods, the gold standard of oral food challenge, and the 'platinum standard' of diagnosis made by a medical expert based on history, skin prick testing and oral food challenge. This is not an epidemiological study but with no published studies on OAS in a UK population, this study will also provide some information on the prevalence of OAS in those with springtime hayfever in the UK.
Condition |
---|
Food Allergy |
Study Type: | Observational |
Study Design: | Cohort |
Official Title: | The Diagnosis of Oral Allergy Syndrome Through the Use of a Structured Questionnaire |
Enrollment: | 123 |
Study Start Date: | May 2005 |
Study Completion Date: | September 2007 |
Primary Completion Date: | September 2006 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Adult subjects aged over 18 years recruited from the general population
Inclusion Criteria:
Exclusion Criteria:
United Kingdom | |
Royal Brompton & Harefield NHS Trust | |
London, United Kingdom, SW3 6NP |
Principal Investigator: | Stephen R Durham, BA, MA, MD, | Imperial College London |
Responsible Party: | Royal Brompton & Harefield NHS Trust ( Isabel Skypala, Director of Rehabilitation and Therapies ) |
Study ID Numbers: | 05/Q0404/38 |
Study First Received: | March 2, 2009 |
Last Updated: | March 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00854958 History of Changes |
Health Authority: | United Kingdom: National Health Service |
Oral Allergy Syndrome Food Pollen |
Food Hypersensitivity Hypersensitivity Hypersensitivity, Immediate |
Food Hypersensitivity Hypersensitivity Pathologic Processes Disease |
Immune System Diseases Syndrome Hypersensitivity, Immediate |