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Sponsors and Collaborators: |
Maastricht Radiation Oncology Maastricht University Medical Center |
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Information provided by: | Maastricht Radiation Oncology |
ClinicalTrials.gov Identifier: | NCT00157443 |
The purpose of this study is to determine, by means of DNA and protein analysis, the relationship between DNA and protein profiles and a number of endpoints which are important for the patient such as overall survival and side effects.
Condition | Intervention |
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Cervix Cancer |
Other: drawing of blood Other: drawing blood |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Storing Blood for Analysis of DNA and Protein of Patients With Cervix Cancer in MAASTRO Clinic |
whole blood
Estimated Enrollment: | 99 |
Study Start Date: | June 2005 |
Estimated Study Completion Date: | January 2025 |
It has already been known for a long time that cancer is a genetic disorder and that the development of the illness is a very complex interaction between genetic and surrounding factors. Also the response on therapy and the development and seriousness of side effects is stipulated by this complicated collaboration of genetic and surrounding factors. Moreover it is not only the DNA that plays an important role but also the systems of control at protein level. At this moment a lot of questions remain to be answered because up till now the studies were of rather restricted statistical strength with frequently inconsistent dates and moreover retrospective. Major retrospective studies are necessary to distinguish the relationship between DNA/protein patterns and clinical relevant endpoints like prognosis and toxicity in which an as broad as possible patient group is being monitored.
For this reason we want to draw blood in MAASTRO clinic of all patients with cervix cancer and store it encrypted so that we can perform DNA and protein analyses in future and to correlate the results with survival and toxicity of the treatment.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
primary care clinic
Inclusion Criteria:
Exclusion Criteria:
Contact: Philippe Lambin, Prof. PHD | +31 (0) 88 44 55 666 | philippe.lambin@maastro.nl |
Contact: Dirk De Ruysscher, PHD | +31 (0) 88 44 55 666 | dirk.deruysscher@maastro.nl |
Netherlands, Limburg | |
Maastricht Radiation Oncology | Recruiting |
Heerlen, Limburg, Netherlands, 6419PC | |
Contact: Dirk De Ruysscher, PHD +31 (0) 88 44 55 666 dirk.deruysscher@maastro.nl | |
Contact: Ludy Lutgens +31 (0) 88 44 55 666 ludy.lutgens@maastro.nl |
Principal Investigator: | Dirk De Ruysscher, PHD | CCMO |
Responsible Party: | Maastricht University Medical Center ( Maastricht Radiation Oncology ) |
Study ID Numbers: | P05.0748L |
Study First Received: | September 8, 2005 |
Last Updated: | September 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00157443 History of Changes |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
cervix carcinoma, genomics, proteomics |
Genital Diseases, Female Uterine Cervical Neoplasms Uterine Cervical Diseases Genital Neoplasms, Female |
Uterine Diseases Uterine Neoplasms Urogenital Neoplasms Carcinoma |
Genital Diseases, Female Uterine Cervical Neoplasms Uterine Cervical Diseases Neoplasms Neoplasms by Site |
Genital Neoplasms, Female Uterine Diseases Uterine Neoplasms Urogenital Neoplasms |