Inclusion Criteria:

• To be eligible to participate in this study, the following criteria must be met:

Subject is or has:

• Male or female outpatient greater than or equal to 18 years of age;
• Suffering presently from neuropathic pain, which has been present for at least 3 months and is clinically felt to be associated with CIAP;
• CIAP defined by the following clinical criteria: Primary = distal predominant sensory loss in feet and/or hands; preserved motor strength and deep tendon reflexes; normal routine nerve conduction study velocities and amplitudes; no identifiable etiology after appropriate evaluation; Secondary = neuropathic pain in feet; neuropathic pain in hands; abnormal QSART, age 45-70 years, autonomic dysfunction.
• Neuropathic pain at entry into the study must meet the following criteria: a VAS of at least 40 mm at visit 2 (to assess pain intensity during the past week) and with an average daily score of at least 4 on the PSS during the baseline period as evaluated on a minimum of 4 days;
• An estimated creatinine clearance of at least 80 ml/min. If the subject has a history or symptoms of renal impairment, an estimated creatinine clearance will be obtained at the baseline visit. If the estimated creatinine clearance is </= 80 ml/min the subject is not eligible to participate;
• Capable of understanding and completing diaries and questions, and adhering to the protocol, in the judgment of the investigator;
• Females of childbearing potential must have a negative serum pregnancy test at the selection visit and at Visits 2 - 6 (and a negative result on the accompanying urine pregnancy test at Visit 2). Females must be surgically sterile, postmenopausal for at least 2 years prior to visit 1, must have undergone tubal ligation or using an acceptable method of birth control for the duration of the study (oral contraceptives must be stable for at least one full month prior to visit 1). Abstinence is not an acceptable method of contraception for the study.
• Written informed consent obtained prior to procedures being performed and the consent process documented;
• Able to follow written and verbal instructions in English or in Spanish and be willing to attend the required study visits and complete the required daily assessments (Spanish speaking patients can only be enrolled at sites with staff who are fluent in Spanish);
• A telephone where they can be directly contacted.

Exclusion Criteria:

• Subjects must be excluded if they meet any of the following criteria.

Subject is or has:

• Receiving professional psychological support (such as cognitive behavioral therapy) currently or within 2 weeks prior to visit 1 specifically for coping with PHN;
• Previous neurolytic or neurosurgical therapy for peripheral neuropathy pain, at any time in the subject's history or treatment with TENS (transelectroneuro stimulation) currently or within the past 2 weeks;
• Known co-existent source of pain or painful peripheral neuropathy, (untreated hypoparathyroidism, vitamin B12 deficiency, amyloidosis, connective tissue disease, porphyria, diabetic peripheral neuropathy, complex regional pain syndrome, alcoholism, hepatitis, uremia, syphilis, myeloma, malignancy (less than 5 years in remission), peripheral nerve trauma (including surgery), drug induced peripheral neuropathy (e.g., vinca alkaloids, taxols, etc.) or other systemic disease associated with a secondary painful neuropathy);
• Known significant neurological disorder other than the study disease or a condition which can mimic stroke with distal neurological deficit (amyotrophy, radiculopathy, history of TIAs, multiple sclerosis, or any amputations);
• Conditions known to be associated with immunosuppressive states;
• Significant lactose intolerance;
• Presence of signs or symptoms of rapidly progressing clinically significant brain disorder or dementia;
• Significant and severe medical conditions (such as severe cardiac dysfunction, bone marrow suppression, severe hepatic disease) which may impair reliable participation in the trial;
• Clinically significant deviations from reference range values for laboratory parameters such as hepatic markers (ALAT/SGPT, ASAT/SGOT, alkaline phosphatase, γGT), platelets < 100,000/μl, leukocyte count < 3500/mm3 or neutrophil cells < 1,800/μl;
• Alcohol or drug abuse currently or within the past year according to DSM-IV-TR criteria as interpreted by the investigator;
• Current participation or participation within the last 30 days in another investigational clinical trial or dosing with any non-study drug not approved for use in the United States;
• Clinically significant major depression defined as a Beck Depression Inventory Score > 21 at selection including those with a history of Bipolar Disorder;
• History of suicidal ideation in the past 3 months or suicide attempt within the last 10 years;
• Intake of more than two classes of medications to treat pain at study entry (see Sectio on Concomitant Treatment);
• Intake of levetiracetam within 2 weeks prior to visit 1;
• Currently receiving treatment with a spinal cord stimulator
• Intake of benzodiazepines (for any indication), skeletal muscle relaxants, orally administered steroids, local and topical agents for the relief of peripheral polyneuropathy pain, and anticonvulsant agents within 2 weeks prior to visit 1 or during the study;
• Discontinued treatment with antidepressants < 4 weeks prior to visit 1;
• Current use or use within 2 weeks prior to visit 1 of topical steroids specifically for the treatment of peripheral neuropathy pain;
• Current use or use within 2 weeks prior to visit 1 of lidocaine patches as a therapy for peripheral neuropathy pain, regardless of frequency or duration of use;
• History of hormone replacement therapy which has not been stable and ongoing for at least 2 weeks prior to visit 1;
• A female subject who is currently breast feeding an infant;
• Presence of an indwelling cardiac pacemaker or other indwelling electrical device that would preclude performance of nerve conduction studies.
• Known hypersensitivity to levetiracetam or any of the inactive ingredients.