Prevalence, Natural History, Prognosis Factor, Quality of Life, Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France - Full Text View

Prevalence, Natural History, Prognosis Factor, Quality of Life, Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France (KHOALA)

This study is currently recruiting participants.

Verified by Central Hospital, Nancy, France, April 2009

First Received: May 31, 2007 Last Updated: April 3, 2009 History of Changes

Sponsored by:	Central Hospital, Nancy, France
Information provided by:	Central Hospital, Nancy, France
ClinicalTrials.gov Identifier:	NCT00481338

Purpose

The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients.

General objectives: To document the natural history and to identify predictive factors of the evolution and consequences of hip and knee OA in terms of pain, functional disability, structural damage, quality of life, autonomy, medical and health care use and cost of disease.

Condition
Hip Osteoarthritis Knee Osteoarthritis

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Knee and Hip OsteoArthritis Long Term Assessment. Prevalence, Natural History, Prognosis Factor, Quality of Life, Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France

Resource links provided by NLM:

MedlinePlus related topics: Osteoarthritis

U.S. FDA Resources

Further study details as provided by Central Hospital, Nancy, France:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Estimated Enrollment:	800
Study Start Date:	April 2007
Estimated Study Completion Date:	March 2019

Eligibility

Ages Eligible for Study:	40 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

General population

Criteria

Inclusion Criteria:

male and female aged between 40 and 75 years
symptomatic hip or knee, uni or bilateral OA with clinical diagnosis confirmed by a medical physician and satisfying ACR classification criteria
Representative of prevalent cases in France at the cohort set-up time

Exclusion Criteria:

presence of hip or knee joint replacement surgery
comorbidities severe enough to affect quality of life significantly or likely to induce a high health care consumption independently of OA
an history of osteotomy
Patello-femoral osteoarthritis without tibio-femoral osteoarthritis
Other joint diseases of the target joints

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00481338

Contacts

Contact: Francis Guillemin, MD, PhD	33383852163	francis.guillemin@chu-nancy.fr
Contact: Anne-Christine Rat, MD, PhD	33383852163	ac.rat@chu-nancy.fr

Locations

France
CHU Nancy, hopital brabois	Recruiting
Nancy, France, 54035
Contact: Francis Guillemin, MD, PhD 33383852163 francis.guillemin@chu-nancy.fr
Contact: Anne-Christine Rat, MD, PhD 33383852163 ac.rat@chu-nancy.fr
Principal Investigator: Francis Guillemin, MD, PhD
Sub-Investigator: Anne-Christine Rat, MD, PhD
CHU de la Cavale Blanche	Recruiting
Brest, France, 29609
Contact: Alain Saraux, MD, PhD 33298347267 alain.saraux@univ-brest.fr
Principal Investigator: Alain Saraux, MD, PhD
CHU Amiens	Recruiting
Amiens, France, 80054
Contact: Patrice Fardellone, MD, PhD 33322668252 fardellone.patrice@chu-amiens.fr
Principal Investigator: Patrice Fardellone, MD, PhD
CHU Rangueil	Recruiting
Toulouse, France, 31059
Contact: Bernard Mazières, MD, PhD 33561322723 mazieres.b@chu-toulouse.fr
Principal Investigator: Bernard Mazières, MD, PhD
Hôpital de la Pitié-Salpêtrière	Recruiting
Paris, France, 75651
Contact: Bruno Fautrel, MD, PhD 33142177821 bruno.fautrel@psl.aphp.fr
Principal Investigator: Bruno Fautrel, MD, PhD
CHU l'Archet	Recruiting
Nice, France, 06202
Contact: Liana Euler-Ziegler, MD, PhD 33492035512 euller-ziegler.l@chu-nice.fr
Contact: Christian Roux, MD 33492035477 roux.cr@chu-nice.fr
Principal Investigator: Liana Euler-Ziegler, MD, PhD
Sub-Investigator: Christian Roux, MD, PhD

Sponsors and Collaborators

Central Hospital, Nancy, France

Investigators

Principal Investigator:

Francis Guillemin, MD, PhD

CHU Nancy (promoteur)

More Information

No publications provided

Responsible Party:	University hospital ( VIGOUROUX Philippe, hospital director )
Study ID Numbers:	DGS2006-0146
Study First Received:	May 31, 2007
Last Updated:	April 3, 2009
ClinicalTrials.gov Identifier:	NCT00481338 History of Changes
Health Authority:	France: Ministry of Health

Keywords provided by Central Hospital, Nancy, France:

Cohort
Quality of life
Health resource use
Disability
Prognosis

Study placed in the following topic categories:

Osteoarthritis, Knee
Musculoskeletal Diseases
Osteoarthritis
Joint Diseases

Arthritis
Quality of Life
Rheumatic Diseases
Osteoarthritis, Hip

Additional relevant MeSH terms:

Osteoarthritis, Knee
Musculoskeletal Diseases
Osteoarthritis
Joint Diseases

Arthritis
Rheumatic Diseases
Osteoarthritis, Hip

ClinicalTrials.gov processed this record on September 11, 2009