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Sponsors and Collaborators: |
Danish Heart Foundation Fonden for Lægevidenskabelig Forskning for Fyns Amt. Novo Nordisk AJ Andersen og Hustrus Fond Overlægerådet Legatudvalg Raimond og Dagmar Ringgård Bohns Fond Bankdirektør Hans Stener og hustru Agnes Steners legat Odense University Hospital |
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Information provided by: | Danish Heart Foundation |
ClinicalTrials.gov Identifier: | NCT00306579 |
Introduction
For several years “ischemic” electrocardiographic (ECG) changes in the acute phase of ischemic stroke have been reported. Whether these ECG changes reflect true myocardial ischemia remains controversial. So far no study has assessed different markers of myocardial ischemia or necrosis in consecutive patients admitted to hospital with an acute ischemic stroke.
Purpose
The main purpose of this study is to determine the potential burden of reversible and irreversible myocardial ischemia in patients with an acute ischemic stroke.
Patients and methods
Serial blood samples for measuring troponin T, CK-MB and NT-proBNP are collected in 250 patients with evidence of an acute ischemic stroke admitted to the Department of Neurology at Odense University Hospital. In addition resting 12-lead ECG recordings will be obtained on a daily basis, and a 24-hour ST-segment ambulatory monitoring will be performed once within the first week of hospitalisation. Finally, myocardial perfusion patterns during rest will be evaluated by means of a myocardial perfusion scintigraphy in patients with an elevated troponin T level. Six months later control measurements of troponin T, CK-MB and NT-proBNP and a 12-lead ECG will be obtained.
Expectations
The study will contribute with original observations in patients with acute ischemic stroke considering the following issues:
The results may have clinical implications regarding early and late treatment as well as clinical follow-up of patients recovering from an episode of acute ischemic stroke.
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Official Title: | Myocardial Damage In Patients With Cerebral Infarction. Prevalence and Characteristics as Measured by Troponins, Electrocardiographic Changes and Myocardial Perfusion Imaging. |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Principal Investigator: | Jesper K. Jensen, MD | Department of Cardiology, Odense University Hospital |
Study Director: | Hans Mickley, DMSci | Department of Cardiology, Odense University Hospital |
Study Chair: | Søren Bak, MD, PhD | Department of Neurology, Odense University Hospital |
Study Chair: | Poul Flemming H. Carlsen, DMSci | Department of Nuclear Medicine, Odense University Hospital |
Study Chair: | Søren R. Kristensen, DMSci | Department of Clinical Chemistry, Aalborg Hospital |
Study ID Numbers: | 054B26A43722225 |
Study First Received: | March 23, 2006 |
Last Updated: | March 23, 2006 |
ClinicalTrials.gov Identifier: | NCT00306579 History of Changes |
Health Authority: | Denmark: National Board of Health |
Ischemic Stroke Myocardial ischemia Myocardial necrosis |
Necrosis Cerebral Infarction Myocardial Ischemia Stroke Vascular Diseases Central Nervous System Diseases |
Brain Ischemia Brain Infarction Ischemia Brain Diseases Infarction Cerebrovascular Disorders |
Cerebral Infarction Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Ischemia Brain Diseases |
Cerebrovascular Disorders Necrosis Pathologic Processes Brain Ischemia Cardiovascular Diseases Brain Infarction Infarction |