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Sponsors and Collaborators: |
Queen's University Canadian Institutes of Health Research (CIHR) |
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Information provided by: | Queen's University |
ClinicalTrials.gov Identifier: | NCT00955071 |
The investigators will randomize abdominally obese men and women at increased health risk to one of the following 4 conditions: 1) No-exercise, wait list controls (C), 2) Low volume, low intensity exercise (LVLI), 3) High volume, low intensity exercise (HVLI), 4) Low volume, high intensity exercise (LVHI).
The primary aim of the trial is to determine the effects of varying exercise dose (energy expenditure, kcal) or intensity (relative to VO2max (cardiorespiratory fitness)) on waist circumference and glucose tolerance. The investigators will test the following hypotheses: 1) That the reduction in waist circumference and improvement in glucose tolerance in response to all treatments will be greater than controls. 2) That reduction in waist circumference and improvement in glucose tolerance in HVLI and LVHI will be greater than LVLI. 3) That hypotheses
1 and 2 are true independent of gender.
Condition | Intervention |
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Obesity Metabolic Syndrome Cardiovascular Disease |
Other: Exercise: LVLI Other: Exercise: HVLI Other: Exercise: LVHI |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind (Investigator), Active Control, Parallel Assignment |
Official Title: | Dose-response Effects of Exercise on Abdominal Obesity and Risk Factors for CVD in Women and Men |
Estimated Enrollment: | 320 |
Study Start Date: | September 2009 |
Estimated Study Completion Date: | September 2013 |
Estimated Primary Completion Date: | September 2013 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Control: No Intervention | |
Exercise: LVLI: Active Comparator
low volume, low intensity
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Other: Exercise: LVLI
low volume, low intensity
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Exercise: HVLI: Active Comparator
high volume, low intensity
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Other: Exercise: HVLI
high volume, low intensity
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Exercise: LVHI: Active Comparator
low volume, high intensity
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Other: Exercise: LVHI
low volume, high intensity
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Ages Eligible for Study: | 40 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Robert Ross, PhD | 613-533-6583 | rossr@queensu.ca |
Canada, Ontario | |
School of Kinesiology and Health Studies, Queen's University | |
Kingston, Ontario, Canada, K7L 3N6 |
Principal Investigator: | Robert Ross, PhD | Queen's University |
Principal Investigator: | Robert Hudson, MD,PhD | Queen's University |
Principal Investigator: | Miu Lam, PhD | Queen's University |
Responsible Party: | Queen's University ( Dr. Robert Ross ) |
Study ID Numbers: | Ross 2009 |
Study First Received: | August 4, 2009 |
Last Updated: | August 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00955071 History of Changes |
Health Authority: | Canada: Health Canada |
exercise physical activity diet |
metabolic risk visceral fat Insulin Resistance |
Body Weight Signs and Symptoms Obesity Nutrition Disorders |
Overweight Overnutrition Insulin Resistance Insulin |
Body Weight Signs and Symptoms Obesity Pathologic Processes Disease |
Syndrome Nutrition Disorders Overweight Overnutrition Cardiovascular Diseases |