Effect of Monosodium Glutamate Supplementation on Gastric Emptying and Postprandial Nitrogen Kinetics

This study has been completed.

First Received: March 13, 2009 No Changes Posted

Sponsors and Collaborators:	Institut National de la Recherche Agronomique AgroParisTech
Information provided by:	Institut National de la Recherche Agronomique
ClinicalTrials.gov Identifier:	NCT00862017

Purpose

There are receptors to free glutamate in the oral cavity and stomach that may mediate effects of this amino acid on gastrointestinal physiology. The investigators hypothesize that a chronic supplementation of monosodium glutamate (MSG) could modulate gastric emptying and the further metabolism of dietary protein in healthy subjects.

Condition	Intervention
Healthy	Dietary Supplement: MSg supplementation Dietary Supplement: NaCl supplementation

Study Type:	Interventional
Study Design:	Basic Science, Randomized, Placebo Control, Crossover Assignment
Official Title:	Effect of Monosodium Glutamate on Gastric Emptying and Postprandial Nitrogen in Healthy Volunteers

Resource links provided by NLM:

MedlinePlus related topics: Dietary Supplements Diets

U.S. FDA Resources

Further study details as provided by Institut National de la Recherche Agronomique:

Enrollment:	13
Study Start Date:	April 2008

Arms	Assigned Interventions
MSG: Experimental Subjects receive a 6-d supplementation of MSG and are studied on the 7th day in the postprandial period following a standard meal ingestion with 2g MSG	Dietary Supplement: MSg supplementation
Control: Placebo Comparator	Dietary Supplement: NaCl supplementation

Eligibility

Ages Eligible for Study:	30 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

BMI 23 to 28

Exclusion Criteria:

pregnancy
allergy to milk protein
gastrointestinal diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00862017

Locations

France
Centre de recherche sur volontaires
Bobigny, France, 93

Sponsors and Collaborators

Institut National de la Recherche Agronomique

AgroParisTech

More Information

No publications provided

Responsible Party:	Assistance Publique - Hopitaux de Paris ( Pr Benamouzig )
Study ID Numbers:	AJI-01
Study First Received:	March 13, 2009
Last Updated:	March 13, 2009
ClinicalTrials.gov Identifier:	NCT00862017 History of Changes
Health Authority:	France: Ministry of Health

Keywords provided by Institut National de la Recherche Agronomique:

Physiology

Study placed in the following topic categories:

Glutamic Acid
Healthy

ClinicalTrials.gov processed this record on September 11, 2009