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Sponsored by: |
Cliniques universitaires Saint-Luc- Université Catholique de Louvain |
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Information provided by: | Cliniques universitaires Saint-Luc- Université Catholique de Louvain |
ClinicalTrials.gov Identifier: | NCT00399815 |
Chronic viral hepatitis C is a frequent liver disease. It is associated with variable degree of hepatic fibrosis.
To date, liver histology is still regarded as the gold standard to detect, diagnose and quantify liver fibrosis.
This requires to perform a liver biopsy. Severe complications are associated to this procedure in 0.01 to 0.1% of cases. Because of this, the repetition of the biopsy to evaluate the progression of the disease or the response to treatment poses ethical questions. Also, liver biopsy only explore a minimal portion of the liver and liver fibrosis, which is not homogeneous, may be under- or over-estimated.
To avoid risks linked to invasive technique and sampling errors associated to liver biopsy, efforts are being made to develop non-invasive technology to detect and quantitate liver fibrosis.
In this study we will perform in patients with chronic hepatitis C, serum tests, fibroscan (elstography of liver parenchyma determined by ultra-sounds), and elastography of liver parenchyma by MRI.
This study will allow
Condition |
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Hepatitis C, Chronic |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Yves J Horsmans, M.D., Ph.D. | 32 2 764 28 37 | horsmans@gaen.ucl.ac.be |
Contact: Bernard VanBeers, M.D., | 32 2 764 29 45 | vanbeers@rdgn.ucl.ac.be |
Belgium | |
Cliniques Universitaires StLuc, Université catholique de Louvain (UCL) | Recruiting |
Brussels, Belgium, 1200 |
Study Director: | Yves J Horsmans, M.D., Ph.D. | Cliniques Universitaires StLuc, Université catholique de Louvain (UCL), Brussels, Belgium |
Study ID Numbers: | ELASTO2 |
Study First Received: | November 14, 2006 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00399815 History of Changes |
Health Authority: | Belgium: Institutional Review Board |
Chronic viral hepatitis C HCV RNA Fibroscan Fibrotest hepatic elastography by MRI |
Virus Diseases Hepatitis Liver Diseases Digestive System Diseases Hepatic Fibrosis |
Hepatitis, Chronic Fibrosis Hepatitis, Viral, Human Hepatitis C Hepatitis C, Chronic |
Virus Diseases Hepatitis RNA Virus Infections Liver Diseases Digestive System Diseases |
Hepatitis, Chronic Flaviviridae Infections Hepatitis, Viral, Human Hepatitis C Hepatitis C, Chronic |