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Sponsored by: |
University Hospital, Strasbourg, France |
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Information provided by: | University Hospital, Strasbourg, France |
ClinicalTrials.gov Identifier: | NCT00399620 |
Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations.
Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.
Condition | Intervention |
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Periodontitis and Diabetitis |
Procedure: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up). |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment |
Official Title: | Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis |
Ages Eligible for Study: | 20 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion criteria:
Exclusion criteria:
Contact: Martine Soell, MD | 33 6 74 86 67 36 | martine.soell@chru-strasbourg.fr |
France | |
Département de Parodontologie - Hôpital Civil | Recruiting |
Strasbourg, France, 67091 | |
Contact: Martine Soell, MD 33.6.74.86.67.36 martine.soell@chru-strasbourg.fr | |
Principal Investigator: Martine Soell, MD | |
Sub-Investigator: Frédéric Blickle, MD |
Study Director: | Martine Soell, MD | Hôpitaux Universitaires de Strasbourg |
Study ID Numbers: | 3739 |
Study First Received: | November 14, 2006 |
Last Updated: | January 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00399620 History of Changes |
Health Authority: | France: Ministry of Health |
Periodontitis Diabetes Gingival crevicular fluid GCF Saliva |
Chromogranin Electrophorèse Western Blot RT-HPLC |
Mouth Diseases Periodontal Diseases Periodontitis Diabetes Mellitus Stomatognathic Diseases |
Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases |