Behavioural Treatment of Hypertension

This study has been completed.

First Received: October 31, 2005 Last Updated: July 23, 2008 History of Changes

Sponsors and Collaborators:	University of British Columbia Canadian Institutes of Health Research (CIHR)
Information provided by:	University of British Columbia
ClinicalTrials.gov Identifier:	NCT00247910

Purpose

The objective of the study is to determine whether psychological therapy (self-help or individualized intense stress management) is different than a single drug treatment in terms of their effectiveness for lowering blood pressure.

Condition	Intervention
Hypertension	Drug: Hydrochlorothiazide

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Behavioural Treatment of Hypertension

Resource links provided by NLM:

MedlinePlus related topics: High Blood Pressure

Drug Information available for: Hydrochlorothiazide

U.S. FDA Resources

Further study details as provided by University of British Columbia:

Primary Outcome Measures:

Day time ambulatory BP [ Time Frame: See description ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

24 hour ambulatory BP, and office resting BP [ Time Frame: See description ] [ Designated as safety issue: No ]

Enrollment:	150
Study Start Date:	October 2001
Study Completion Date:	June 2006
Primary Completion Date:	June 2006 (Final data collection date for primary outcome measure)

Intervention Details:

Not recorded in detailed description.

Detailed Description:

Eligibility

Ages Eligible for Study:	19 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

must be at least 19 years of age
subjects can be male or female
subjects must have an average resting blood pressure of >140 systolic pressure an/ or >90 diastolic pressure off anti-hypertensive medication

Exclusion Criteria:

must not be on more than 2 blood pressure lowering drugs
must not have known or suspected of having secondary hypertension on initial examination
must not be pregnant or anticipating pregnancy during study period
must not have history of allergy, hypersensitivity or intolerance to diuretics
must not have medical condition that may result in an unacceptable risk of complications due to uncontrolled hypertension during time period of study
must not have average resting BP readings that exceed 190 systolic, or 115 diastolic, or have two consecutive readings of 180 systolic or 110 diastolic

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00247910

Locations

Canada, British Columbia
UBC Hospital
Vancouver, British Columbia, Canada, V6T 2B5

Sponsors and Collaborators

University of British Columbia

Canadian Institutes of Health Research (CIHR)

Investigators

Principal Investigator:

Wolfgang Linden, PhD

University of British Columbia

More Information

Additional Information:

Related Info This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party:	University of British Columbia ( Dr. Wolfgang Linden )
Study ID Numbers:	C01-0175
Study First Received:	October 31, 2005
Last Updated:	July 23, 2008
ClinicalTrials.gov Identifier:	NCT00247910 History of Changes
Health Authority:	Canada: Health Canada

Keywords provided by University of British Columbia:

hypertension, ambulatory BP, office resting BP, hydrochlorothiazide, stress reduction, self-help, psychotherapy, efficacy

Study placed in the following topic categories:

Sodium Chloride Symporter Inhibitors
Diuretics
Vascular Diseases
Stress

Cardiovascular Agents
Antihypertensive Agents
Hydrochlorothiazide
Hypertension

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Diuretics
Physiological Effects of Drugs
Sodium Chloride Symporter Inhibitors
Vascular Diseases
Cardiovascular Agents
Antihypertensive Agents

Hydrochlorothiazide
Pharmacologic Actions
Membrane Transport Modulators
Natriuretic Agents
Therapeutic Uses
Cardiovascular Diseases
Hypertension

ClinicalTrials.gov processed this record on September 10, 2009