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Sponsors and Collaborators: |
GlaxoSmithKline None |
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Information provided by: | GlaxoSmithKline |
ClinicalTrials.gov Identifier: | NCT00453778 |
Investigate if asthmatics treated with FLIXOTIDE (FP) 500 mcg BID during 14 days get reduced bronchial reactivity after inhalation of Leukotriene D4. Two 14 days treatment periods where patients received FP 500 MCG BID and placebo. Washout at least 21 days between treatments. Bronchial challenge with methacholine and Leukotriene D4 were performed before the start of each treatment period and on treatment days 13 and 14 respectively.
Condition | Intervention |
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Mild Asthma |
Drug: FLIXOTIDE Diskus 500 mcg (Fluticasone Propionate) |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | A Study to Investigate the Effect of Inhaled Fluticasone Propionate on the Bronchial Responsiveness to Leukotriene D4 in Asthmatics Patients |
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion:
Exclusion:
Study ID Numbers: | FMS40273, FMS40273 |
Study First Received: | March 27, 2007 |
Last Updated: | April 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00453778 History of Changes |
Health Authority: | Sweden: Medical Products Agency |
mild asthma bronchial challenge methacholine leukotriene D4 FLIXOTIDE |
Anti-Inflammatory Agents Methacholine Chloride Anti-Asthmatic Agents Fluticasone |
Asthma Anti-Allergic Agents Peripheral Nervous System Agents Bronchodilator Agents |
Anti-Inflammatory Agents Respiratory System Agents Autonomic Agents Therapeutic Uses Physiological Effects of Drugs Anti-Asthmatic Agents |
Fluticasone Anti-Allergic Agents Peripheral Nervous System Agents Dermatologic Agents Bronchodilator Agents Pharmacologic Actions |