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| Sponsored by: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
|---|---|
| Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| ClinicalTrials.gov Identifier: | NCT00081562 |
Purpose
Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.
| Condition |
|---|
|
Spondylitis Ankylosing Spondylitis |
| Study Type: | Observational |
| Official Title: | Family Studies of the Genetics of Ankylosing Spondylitis |
| Estimated Enrollment: | 1600 |
| Study Start Date: | September 1999 |
| Study Completion Date: | December 2006 |
| Primary Completion Date: | December 2006 (Final data collection date for primary outcome measure) |
AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of AS is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender.
This study will collect patient information and blood samples from affected patients (and when available, both parents of the affected patients) of 400 families with children fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs.
Information from these patients will be used to search the human genome for disease-associated loci and/or genes.
This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Contacts and Locations| United States, California | |
| Cedars-Sinai Medical Center | |
| Los Angeles, California, United States, 90048 | |
| United States, Texas | |
| University of Texas - Health Science Center at Houston | |
| Houston, Texas, United States, 77030 | |
| Principal Investigator: | John D. Reveille, MD | The University of Texas Health Science Center, Houston |
More Information
| Study ID Numbers: | NIAMS-098, 5R01 AR046208-05, NASC |
| Study First Received: | April 15, 2004 |
| Last Updated: | February 19, 2008 |
| ClinicalTrials.gov Identifier: | NCT00081562 History of Changes |
| Health Authority: | United States: Federal Government |
|
Spinal Diseases Musculoskeletal Diseases Spondylarthropathy Arthritis Joint Diseases Spondylitis, Ankylosing |
Spondylarthritis Bone Diseases Spondylitis Ankylosis Spondylarthropathies |
|
Spinal Diseases Musculoskeletal Diseases Arthritis Joint Diseases Spondylitis, Ankylosing Infection |
Spondylarthritis Bone Diseases Spondylitis Ankylosis Spondylarthropathies Bone Diseases, Infectious |
