Cognition, Steroids, and Imaging in Cushings Disease

This study has been completed.

First Received: April 8, 2004 Last Updated: October 9, 2007 History of Changes

Sponsored by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00081341

Purpose

This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function.

Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions.

Condition
Cushing Syndrome

Study Type:	Observational
Study Design:	Prospective
Official Title:	Cognition, Steroids, and Imaging in Cushings Disease

Resource links provided by NLM:

MedlinePlus related topics: Cushing's Syndrome

U.S. FDA Resources

Eligibility

Ages Eligible for Study:	9 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion criteria:

patients with suspected Cushing's syndrome with clinical findings suggestive of Cushing's syndrome and positive screening tests (urinary free cortisol and low dose overnight dexamethasone suppression test).

Exclusion criteria: none

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00081341

Locations

United States, Michigan
General Clinical Research Center, University of Michigan Health System
Ann Arbor, Michigan, United States, 48109

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

No publications provided

Study ID Numbers:	51337DK
Study First Received:	April 8, 2004
Last Updated:	October 9, 2007
ClinicalTrials.gov Identifier:	NCT00081341 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Hypothalamic Diseases
Pituitary ACTH Hypersecretion
Pituitary Diseases
Cushing Syndrome
Central Nervous System Diseases

Endocrine System Diseases
Adrenal Gland Diseases
Endocrinopathy
Brain Diseases
Adrenocortical Hyperfunction

Additional relevant MeSH terms:

Hypothalamic Diseases
Disease
Pituitary Diseases
Nervous System Diseases
Cushing Syndrome
Adrenal Gland Diseases
Endocrine System Diseases

Central Nervous System Diseases
Brain Diseases
Adrenocortical Hyperfunction
Pituitary ACTH Hypersecretion
Pathologic Processes
Hyperpituitarism
Syndrome

ClinicalTrials.gov processed this record on September 10, 2009