Inclusion Criteria:

1. Males or females
2. Control (Adult) group: aged between 18 and 65 years (inclusive)
3. Elderly group: aged > 65 years (includes subjects 1 day or more beyond the 65th birthday)
4. Able to give signed informed consent
5. BMI 27-45 kg/m2, inclusive 6. Eligible male and female subjects must agree not to participate in a conception process (i.e. active attempt to become pregnant or to impregnate, egg or sperm donation, in vitro fertilization).
6. Considered to be in stable health in the opinion of the Investigator

Exclusion Criteria:

1. Prior participation in any study of lorcaserin.
2. Clinically significant new illness in the 1 month before screening
3. Not suitable to participate in the study in the opinion of the Investigator including an existing physical or mental condition that prevents compliance with the protocol

4. History of any of the following cardiovascular conditions:

   • Myocardial infarction (diagnosed by cardiac enzyme[s] and/or diagnostic ECG), cerebral vascular accident (CVA), transient ischemic attack (TIA) or reversible ischemic neurologic deficit (RIND) within 6 months of screening
   • Cardiac arrhythmia requiring initiation of new medical or surgical treatment within 6 months of screening (stable medical therapy for > 6 months, pacemakers and/or defibrillators implanted > 6 months prior to screening are acceptable)
   • Unstable angina
   • History of pulmonary artery hypertension
5. Positive result of HIV, hepatitis B or hepatitis C screens
6. Initiation of a new prescription medication within 1 month prior to screening with the following exceptions:
7. Use of SSRIs, SNRIs, and other medications must meet washout period.
8. Participated in any clinical study with an investigational drug, biologic, or device within 1 month prior to screening