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Sponsored by: |
University of Wuerzburg |
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Information provided by: | University of Wuerzburg |
ClinicalTrials.gov Identifier: | NCT00454103 |
The improvement of conventional imaging techniques has led to an increased detection rate of different adrenal tumors. Since those tumors can belong to a variety of entities the therapeutic consequences also show considerable variation. In order to definitely determine the type of tumor, invasive procedures like CT guided biopsies are often required, which could be avoided by a tumor specific imaging method. The presently available scintigraphic procedures are either time consuming and lead to high radiation exposure or are technically demanding. The steroidogenic enzymes CYP11B1 (11ß-hydroxylase)and CYP11B2 (aldosterone synthase)are expressed exclusively in the adrenal cortex and therefore represent suitable targets for a specific imaging technique. In our project we evaluate 123I-Iodometomidate which binds to both CYP11B enzymes as radiotracer for adrenal scintigraphy.
Condition | Intervention | Phase |
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Adrenal Tumor Adrenocortical Carcinoma |
Drug: 123I-Iodometomidate |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study |
Ages Eligible for Study: | 30 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Stefanie Hahner, MD | 0049 931 201 1 | hahner_s@medizin.uni-wuerzburg.de |
Contact: Andreas Schirbel, PhD | 0049 9331 201 35879 | schirbel_a@klinik.uni-wuerzburg.de |
Germany | |
Recruiting | |
Wuerzburg, Germany, D-97080 | |
Contact: Stefanie Hahner, MD 0049 931 201 1 hahner_s@medizin.uni-wuerzburg.de | |
Contact: Andreas Schirbel, PhD 0049 931 201 35879 schirbel_a@klinik.uni-wuerzburg.de | |
Principal Investigator: Stefanie Hahner, MD | |
Principal Investigator: Andreas Schirbel, PhD | |
Principal Investigator: Bruno Allolio, MD | |
Sub-Investigator: Michael Kreissl, MD |
Principal Investigator: | Christoph Reiners, MD | University of Wuerzburg |
Study ID Numbers: | Wue_123IMTO_100/05 |
Study First Received: | March 28, 2007 |
Last Updated: | October 9, 2007 |
ClinicalTrials.gov Identifier: | NCT00454103 History of Changes |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
adrenocortical carcinoma (ACC) adrenal tumor metastastic adrenocortical carcinoma |
Adrenal Gland Neoplasms Adrenocortical Carcinoma Endocrine System Diseases Adrenal Gland Diseases Endocrinopathy Adrenal Cortex Neoplasms |
Epinephrine Adrenal Cortex Diseases Adenocarcinoma Neoplasms, Glandular and Epithelial Endocrine Gland Neoplasms Carcinoma |
Neoplasms by Histologic Type Adrenocortical Carcinoma Adrenal Gland Diseases Endocrine System Diseases Carcinoma Neoplasms Adrenal Gland Neoplasms |
Neoplasms by Site Adrenal Cortex Neoplasms Adenocarcinoma Adrenal Cortex Diseases Endocrine Gland Neoplasms Neoplasms, Glandular and Epithelial |