Inclusion Criteria:

• Age 18 or older;
• Patient with moderate to severe plaque psoriasis for whom a decision to use etanercept has been made (insurance coverage, if applicable, needs to be determined before screening);
• At the investigator discretion, patient who would benefit from systemic therapy;
• PASI ≥ 10 and BSA ≥ 10 at day 0;
• Unless surgically sterile (or at least 1 year post-menopausal for women), abstinent or homosexual, patient (men and women) willing to use adequate contraceptive method for at least 30 days before Day 0 and until one month after the last drug administration;
• Patient capable of giving informed consent;
• Patient with normal or non clinically significant chest X ray within six months of screening;
• Patient with negative PPD within 3 months of Day 0;
• Negative urine pregnancy test for women of childbearing potential

Exclusion Criteria:

• Patient used topical steroid, topical tar preparations, or other anti-psoriatic preparations except tar or salicylic acid shampoo or hydrocortisone for the face, scalp, genital and inframammary areas within two weeks of Day 0;
• Patient with presence of erythrodermic, pustular or a predominantly guttate psoriasis;
• At the investigator's discretion, patient with any significant infection within 30 days of screening or a patient at risk of septicemia;
• Patient with evidence of any skin condition that would interfere with the evaluation of psoriasis;
• Patient used investigational drugs within 12 weeks or three half-life of Day 0 whichever is longer;
• Patient used systemic anti-psoriatic drugs such as steroids, retinoids, methotrexate, cyclosporine within four weeks of Day 0;
• Patient used any biologic such as alefacept, etanercept, efalizumab, infliximab and adalimumab within 12 weeks of Day 0;
• Patient used ultraviolet light therapy (UVB or nbUVB) within four weeks of Day 0 or PUVA within eight weeks of Day 0;
• Patient with prior or concurrent use of cyclophosphamide;
• Patient with concurrent sulfasalazine therapy or concurrent use of anakinra;
• Patient with an unstable or serious medical condition as defined by the investigator or presence of any significant medical condition that might cause this study to be detrimental to the patient.
• Uncontrolled or severe comorbidities such as diabetes mellitus requiring insulin; congestive heart failure (NYHA class III or IV) or history of myocardial infarction or cerebrovascular accident or transient ischemic attack within three months of screening visit; unstable angina pectoris; uncontrolled hypertension, oxygen-dependent severe pulmonary disease;
• Patient with a known sero-positivity for HIV virus or history of any other immunosuppressing disease;
• Patient with active or chronic hepatitis B or C;
• Patient with any active or chronic infection within four weeks before screening or between the screening and baseline visits;
• Patient with any mycobacterial disease, patient with a positive PPD, a chest X-Ray suggestive of tuberculosis or patient taking anti-tuberculosis medication;
• Patient with a known hypersensitivity to etanercept or one of its components or known to have antibodies to etanercept;
• Patient who received a live attenuated vaccines within 12 weeks of Day 0 or plan to receive one during the study;
• Current pregnancy or lactation;
• At the investigator's discretion, patient with current or history of alcohol or drug abuse that would interfere with the ability of the patient to comply with the study protocol;
• Patient with systemic lupus erythematosus or demyelinating disorder (optic neuritis, multiple sclerosis or other);
• Patient with a history of cancer within five years of Day 0 or presence of cancer except for treated basal or squamous cell carcinoma and in situ cervix carcinoma;
• Patient who failed to respond to nbUVB in the past;
• Patient who have a contra-indication to nbUVB;
• Patient with latex sensitivity (applicable only if they are using prefilled syringe or prefilled SureClickTM autoinjector presentations);
• Patient with a history of non-compliance with other therapies.