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Sponsors and Collaborators: |
University of Washington National Institute of General Medical Sciences (NIGMS) |
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Information provided by: | University of Washington |
ClinicalTrials.gov Identifier: | NCT00638521 |
Organ failure following trauma is a leading cause of morbidity and mortality. It appears that the development of organ failure is a direct result of an altered immune response. This altered response results in the production of circulating factors in the blood that causes direct injury to the injured patients' organs. The mechanism in which this altered immune response occurs is unknown. Based on work we have performed in our laboratory, we believe that this response is initiated on the cell membrane of particular immune cells known as macrophages.
Although the cell membrane may appear uniform, it is not. The membrane is composed of specific segments that allow proteins to associate with each other forming receptors that are required for immune cell activation.
These specific membrane components are composed of various lipids and cholesterol, and have been termed lipid rafts. Based on our laboratory work it appears that these lipid rafts can be altered following injury. In particular both the lipid and protein content within these raft segments may be altered allowing immune cells to become active leading to the production of factors that directly injure normal cells and organs. Thus, we plan to examine if these laboratory findings can be seen in patients suffering from trauma who develop clinical organ failure at Harborview Medical Center. If this is accomplished, this data will lead to the development of both prognostic and therapeutic interventions for the optimal care of injured patient
Condition |
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Severe Trauma |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Trauma and Sepsis Induced Changes in Immune-Cell Membrane Receptor Trafficking |
whole blood
Estimated Enrollment: | 250 |
Study Start Date: | June 2008 |
Estimated Study Completion Date: | August 2012 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion criteria:
Inclusion Criteria:
Exclusion Criteria:
United States, Washington | |
Harborview Medical Center | Recruiting |
Seattle, Washington, United States, 98104 | |
Contact: Laura V Hennessy, RN 206-744-7723 hennessy@u.washington.edu |
Principal Investigator: | Joseph Cuschieri, MD | University of Washington |
Responsible Party: | University of Washington ( Joseph Cuschieri, MD: Associate Professor, Department of Surgery ) |
Study ID Numbers: | 31888-A, GM078054-01 |
Study First Received: | March 12, 2008 |
Last Updated: | June 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00638521 History of Changes |
Health Authority: | United States: Institutional Review Board |
lipids proteins membrane lipid raft |
Sepsis Wounds and Injuries |