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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00240227 |
This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent veterans. Both the study medication period and the placebo period are each 4 weeks in duration.
Condition | Intervention |
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Alcoholism Cocaine Dependence |
Drug: Prazosin |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study |
Official Title: | The Role of the Alpha 1-Adrenergic Antagonist, Prazosin, in the Reduction of Craving and Relapse in Alcohol and Cocaine-Dependent Individuals: a Double-Blind, Randomized, Controlled Clinical Trial |
Enrollment: | 32 |
Study Start Date: | April 2004 |
Study Completion Date: | January 2009 |
Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1
Prazosin vs. placebo
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Drug: Prazosin
FDA approved medication for hypertension
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Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Washington | |
VA Puget Sound Health Care System | |
Seattle, Washington, United States, 98109 |
Principal Investigator: | Andrew J. Saxon, MD | Puget Sound Veterans Administration Health Care System |
Responsible Party: | Department of Veterans Affairs ( Saxon, Andrew - Principal Investigator ) |
Study ID Numbers: | REAP 05-0020 |
Study First Received: | October 13, 2005 |
Last Updated: | April 8, 2009 |
ClinicalTrials.gov Identifier: | NCT00240227 History of Changes |
Health Authority: | United States: Federal Government |
Alcoholism Cocaine Dependence Prazosin Substance use disorders |
Dopamine Uptake Inhibitors Cocaine-Related Disorders Neurotransmitter Agents Adrenergic Agents Central Nervous System Depressants Anesthetics Disorders of Environmental Origin Adrenergic alpha-Antagonists Cardiovascular Agents Antihypertensive Agents Anesthetics, Local Dopamine |
Mental Disorders Prazosin Alcoholism Substance-Related Disorders Vasoconstrictor Agents Dopamine Agents Alcohol-Related Disorders Adrenergic Antagonists Peripheral Nervous System Agents Cocaine Ethanol |
Dopamine Uptake Inhibitors Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Adrenergic Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Disorders of Environmental Origin Anesthetics Prazosin Mental Disorders Sensory System Agents Therapeutic Uses Vasoconstrictor Agents Substance-Related Disorders |
Alcohol-Related Disorders Cocaine Cocaine-Related Disorders Central Nervous System Depressants Cardiovascular Agents Adrenergic alpha-Antagonists Antihypertensive Agents Pharmacologic Actions Anesthetics, Local Alcoholism Adrenergic Antagonists Dopamine Agents Peripheral Nervous System Agents Central Nervous System Agents |